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Causal Mechanistic Flows with regulons in program Pr-11

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Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
AHNAK2	down-regulates	IRF1	activates	R-177	-0.0462797	38	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	CREB1	activates	R-278	-2.27835	6	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	up-regulates	MAZ	represses	R-499	-2.32628	17	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	MAFK	activates	R-2804	-2.38089	14	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	FOXP1	activates	R-3132	-2.58418	19	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	FOXJ2	activates	R-1439	-2.93208	19	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	SPDEF	activates	R-1966	-2.98845	10	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	FOXO1	activates	R-1405	-3.01812	19	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	ZEB1	activates	R-2241	-3.39487	14	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
AHNAK2	down-regulates	ZFX	activates	R-1921	-3.52781	11	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526

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Regulons in program Pr-11

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Regulon	Cox Hazard Ratio	# genes	# causal flows
R-3173	-2.7488	7	5
R-3132	-2.58418	19	6
R-3061	-2.35701	7	1
R-3025	-1.67565	7	9
R-2804	-2.38089	14	10
R-2772	-2.97174	17	2
R-2241	-3.39487	14	7
R-2198	-2.73148	14	5
R-2079	-2.55743	12	5
R-2060	-3.20143	22	2

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Genes in program Pr-11

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EnsEMBL Id	Entrez Id	Preferred
ENSG00000175711	146712	B3GNTL1
ENSG00000206053	90861	JPT2
ENSG00000250510	27239	GPR162
ENSG00000254470	91056	AP5B1
ENSG00000257594	8693	GALNT4
ENSG00000258947	10381	TUBB3
ENSG00000261652	145788	C15orf65

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