Program

Causal Mechanistic Flows with regulons in program Pr-11

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesIRF1activatesR-177-0.046279738Pr-11
BAI3down-regulatesIRF1activatesR-177-0.046279738Pr-11
NRASup-regulatesMZF1repressesR-3025-1.675657Pr-11
RNASeq_FGFR3_Calldown-regulatesMZF1repressesR-3025-1.675657Pr-11
RNASeq_MAFA_Calldown-regulatesMZF1repressesR-3025-1.675657Pr-11
t(14;16)down-regulatesMZF1repressesR-3025-1.675657Pr-11
t(4;14)down-regulatesMZF1repressesR-3025-1.675657Pr-11
amp1qdown-regulatesMZF1repressesR-3025-1.675657Pr-11
del13down-regulatesMZF1repressesR-3025-1.675657Pr-11
t(14;16)_cytogeneticdown-regulatesMZF1repressesR-3025-1.675657Pr-11
t(4;14)_cytogeneticdown-regulatesMZF1repressesR-3025-1.675657Pr-11
MAGEC1down-regulatesKLF7activatesR-284-2.2213410Pr-11
NRASdown-regulatesKLF7activatesR-284-2.2213410Pr-11
t(11;14)down-regulatesKLF7activatesR-284-2.2213410Pr-11
t(14;16)up-regulatesKLF7activatesR-284-2.2213410Pr-11
MYCdown-regulatesKLF7activatesR-284-2.2213410Pr-11
SYNE1down-regulatesKLF7activatesR-284-2.2213410Pr-11
amp1qup-regulatesKLF7activatesR-284-2.2213410Pr-11
del13up-regulatesKLF7activatesR-284-2.2213410Pr-11
t(11;14)_cytogeneticdown-regulatesKLF7activatesR-284-2.2213410Pr-11
AHNAK2down-regulatesCREB1activatesR-278-2.278356Pr-11
FAT3down-regulatesCREB1activatesR-278-2.278356Pr-11
t(14;16)up-regulatesCREB1activatesR-278-2.278356Pr-11
TP53down-regulatesCREB1activatesR-278-2.278356Pr-11
TRAF3up-regulatesCREB1activatesR-278-2.278356Pr-11
amp1qup-regulatesCREB1activatesR-278-2.278356Pr-11
del13up-regulatesCREB1activatesR-278-2.278356Pr-11
AHNAK2up-regulatesMAZrepressesR-499-2.3262817Pr-11
FAT3up-regulatesMAZrepressesR-499-2.3262817Pr-11
TP53up-regulatesMAZrepressesR-499-2.3262817Pr-11
FAT3up-regulatesXBP1repressesR-3061-2.357017Pr-11
AHNAK2down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
ASXL3down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
FAT3down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
KALRNdown-regulatesMAFKactivatesR-2804-2.3808914Pr-11
MYO10down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
PTPRDdown-regulatesMAFKactivatesR-2804-2.3808914Pr-11
SYNE1down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
TACC2down-regulatesMAFKactivatesR-2804-2.3808914Pr-11
amp1qup-regulatesMAFKactivatesR-2804-2.3808914Pr-11
del13up-regulatesMAFKactivatesR-2804-2.3808914Pr-11
RNASeq_FGFR3_Callup-regulatesPRDM1activatesR-2079-2.5574312Pr-11
t(4;14)up-regulatesPRDM1activatesR-2079-2.5574312Pr-11
amp1qup-regulatesPRDM1activatesR-2079-2.5574312Pr-11
del13up-regulatesPRDM1activatesR-2079-2.5574312Pr-11
t(4;14)_cytogeneticup-regulatesPRDM1activatesR-2079-2.5574312Pr-11
AHNAK2down-regulatesFOXP1activatesR-3132-2.5841819Pr-11
PCDH10down-regulatesFOXP1activatesR-3132-2.5841819Pr-11
t(14;16)up-regulatesFOXP1activatesR-3132-2.5841819Pr-11
TACC2down-regulatesFOXP1activatesR-3132-2.5841819Pr-11
amp1qup-regulatesFOXP1activatesR-3132-2.5841819Pr-11
del13up-regulatesFOXP1activatesR-3132-2.5841819Pr-11
FAT3down-regulatesNFATC1activatesR-2198-2.7314814Pr-11
NRASdown-regulatesNFATC1activatesR-2198-2.7314814Pr-11
t(14;16)up-regulatesNFATC1activatesR-2198-2.7314814Pr-11
ZNF208down-regulatesNFATC1activatesR-2198-2.7314814Pr-11
del13up-regulatesNFATC1activatesR-2198-2.7314814Pr-11
KALRNdown-regulatesTCF7L1activatesR-3173-2.74887Pr-11
PTPRDdown-regulatesTCF7L1activatesR-3173-2.74887Pr-11
TACC2down-regulatesTCF7L1activatesR-3173-2.74887Pr-11
TP53down-regulatesTCF7L1activatesR-3173-2.74887Pr-11
del13up-regulatesTCF7L1activatesR-3173-2.74887Pr-11
AHNAK2down-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
ASXL3down-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
MAGEC1down-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
t(14;16)up-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
t(4;14)up-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
TACC2down-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
amp1qup-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
del13up-regulatesFOXJ2activatesR-1439-2.9320819Pr-11
t(11;14)down-regulatesFOXO3activatesR-2772-2.9717417Pr-11
t(11;14)_cytogeneticdown-regulatesFOXO3activatesR-2772-2.9717417Pr-11
AHNAK2down-regulatesSPDEFactivatesR-1966-2.9884510Pr-11
t(11;14)down-regulatesSPDEFactivatesR-1966-2.9884510Pr-11
TP53down-regulatesSPDEFactivatesR-1966-2.9884510Pr-11
amp1qup-regulatesSPDEFactivatesR-1966-2.9884510Pr-11
del13up-regulatesSPDEFactivatesR-1966-2.9884510Pr-11
AHNAK2down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
ASXL3down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
BAI3down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
FAT3down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
MAGI1down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
TACC2down-regulatesFOXO1activatesR-1405-3.0181219Pr-11
del13up-regulatesFOXO1activatesR-1405-3.0181219Pr-11
t(14;16)up-regulatesARID5AactivatesR-603-3.170099Pr-11
TACC2down-regulatesARID5AactivatesR-603-3.170099Pr-11
amp1qup-regulatesARID5AactivatesR-603-3.170099Pr-11
del13up-regulatesARID5AactivatesR-603-3.170099Pr-11
t(14;16)down-regulatesTCF3repressesR-2060-3.2014322Pr-11
ZNF208up-regulatesTCF3repressesR-2060-3.2014322Pr-11
AHNAK2down-regulatesZEB1activatesR-2241-3.3948714Pr-11
t(11;14)down-regulatesZEB1activatesR-2241-3.3948714Pr-11
t(14;16)up-regulatesZEB1activatesR-2241-3.3948714Pr-11
TACC2down-regulatesZEB1activatesR-2241-3.3948714Pr-11
amp1qup-regulatesZEB1activatesR-2241-3.3948714Pr-11
del13up-regulatesZEB1activatesR-2241-3.3948714Pr-11
t(11;14)_cytogeneticdown-regulatesZEB1activatesR-2241-3.3948714Pr-11
AHNAK2down-regulatesZFXactivatesR-1921-3.5278111Pr-11
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-1921-3.5278111Pr-11
MYCdown-regulatesZFXactivatesR-1921-3.5278111Pr-11
t(4;14)up-regulatesZFXactivatesR-1921-3.5278111Pr-11
TP53down-regulatesZFXactivatesR-1921-3.5278111Pr-11
amp1qup-regulatesZFXactivatesR-1921-3.5278111Pr-11
del13up-regulatesZFXactivatesR-1921-3.5278111Pr-11
t(4;14)_cytogeneticup-regulatesZFXactivatesR-1921-3.5278111Pr-11
AHNAK2down-regulatesSTAT3activatesR-307-3.6194110Pr-11
ASXL3down-regulatesSTAT3activatesR-307-3.6194110Pr-11
FAT3down-regulatesSTAT3activatesR-307-3.6194110Pr-11
NRASdown-regulatesSTAT3activatesR-307-3.6194110Pr-11
RNASeq_FGFR3_Callup-regulatesSTAT3activatesR-307-3.6194110Pr-11
t(14;16)up-regulatesSTAT3activatesR-307-3.6194110Pr-11
MYCdown-regulatesSTAT3activatesR-307-3.6194110Pr-11
t(4;14)up-regulatesSTAT3activatesR-307-3.6194110Pr-11
SYNE1down-regulatesSTAT3activatesR-307-3.6194110Pr-11
TACC2down-regulatesSTAT3activatesR-307-3.6194110Pr-11
TP53down-regulatesSTAT3activatesR-307-3.6194110Pr-11
ZNF462down-regulatesSTAT3activatesR-307-3.6194110Pr-11
amp1qup-regulatesSTAT3activatesR-307-3.6194110Pr-11
del13up-regulatesSTAT3activatesR-307-3.6194110Pr-11
t(11;14)_cytogeneticdown-regulatesSTAT3activatesR-307-3.6194110Pr-11
t(4;14)_cytogeneticup-regulatesSTAT3activatesR-307-3.6194110Pr-11
AHNAK2down-regulatesFOXK1activatesR-1196-3.8077415Pr-11
ASXL3down-regulatesFOXK1activatesR-1196-3.8077415Pr-11
FAT3down-regulatesFOXK1activatesR-1196-3.8077415Pr-11
KALRNdown-regulatesFOXK1activatesR-1196-3.8077415Pr-11
PTPRDdown-regulatesFOXK1activatesR-1196-3.8077415Pr-11
t(4;14)up-regulatesFOXK1activatesR-1196-3.8077415Pr-11
SYNE1down-regulatesFOXK1activatesR-1196-3.8077415Pr-11
TACC2down-regulatesFOXK1activatesR-1196-3.8077415Pr-11
amp1qup-regulatesFOXK1activatesR-1196-3.8077415Pr-11
del13up-regulatesFOXK1activatesR-1196-3.8077415Pr-11
BAI3down-regulatesPLAG1activatesR-1526-4.471578Pr-11
KDM3Bdown-regulatesPLAG1activatesR-1526-4.471578Pr-11
t(11;14)down-regulatesPLAG1activatesR-1526-4.471578Pr-11
ROBO2down-regulatesPLAG1activatesR-1526-4.471578Pr-11
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-1526-4.471578Pr-11

Regulons in program Pr-11

Regulon Cox Hazard Ratio # genes # causal flows
R-177-0.0462797382
R-3025-1.6756579
R-284-2.22134109
R-278-2.2783567
R-499-2.32628173
R-3061-2.3570171
R-2804-2.380891410
R-2079-2.55743125
R-3132-2.58418196
R-2198-2.73148145
R-3173-2.748875
R-1439-2.93208198
R-2772-2.97174172
R-1966-2.98845105
R-1405-3.01812197
R-603-3.1700994
R-2060-3.20143222
R-2241-3.39487147
R-1921-3.52781118
R-307-3.619411016
R-1196-3.807741510
R-1526-4.4715785

Genes in program Pr-11

EnsEMBL IdEntrez IdPreferred
ENSG00000175711 146712B3GNTL1
ENSG00000206053 90861JPT2
ENSG00000250510 27239GPR162
ENSG00000254470 91056AP5B1
ENSG00000257594 8693GALNT4
ENSG00000258947 10381TUBB3
ENSG00000261652 145788C15orf65

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions