Program

Causal Mechanistic Flows with regulons in program Pr-105

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)up-regulatesENSG00000176399repressesR-10720.03764658Pr-105
t(11;14)_cytogeneticup-regulatesENSG00000176399repressesR-10720.03764658Pr-105
t(11;14)up-regulatesFOXJ3repressesR-2880-0.54948929Pr-105
del17down-regulatesFOXJ3repressesR-2880-0.54948929Pr-105
t(11;14)_cytogeneticup-regulatesFOXJ3repressesR-2880-0.54948929Pr-105
DIS3down-regulatesHMGA1activatesR-821-0.98831320Pr-105
t(11;14)down-regulatesHMGA1activatesR-821-0.98831320Pr-105
t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-821-0.98831320Pr-105
t(11;14)up-regulatesFOXJ2repressesR-1432-1.0218428Pr-105
t(11;14)up-regulatesPOU2F1repressesR-81-1.3671430Pr-105
del17down-regulatesPOU2F1repressesR-81-1.3671430Pr-105
t(11;14)_cytogeneticup-regulatesPOU2F1repressesR-81-1.3671430Pr-105
IRF4up-regulatesHMBOX1repressesR-2380-1.458648Pr-105
PKHD1up-regulatesHMBOX1repressesR-2380-1.458648Pr-105
t(11;14)up-regulatesHMBOX1repressesR-2380-1.458648Pr-105
t(11;14)_cytogeneticup-regulatesHMBOX1repressesR-2380-1.458648Pr-105
MAXdown-regulatesZBTB16repressesR-582-1.6552515Pr-105
t(11;14)up-regulatesZBTB16repressesR-582-1.6552515Pr-105
t(11;14)_cytogeneticup-regulatesZBTB16repressesR-582-1.6552515Pr-105
BAI3down-regulatesTCF4activatesR-3000-1.6876212Pr-105
FGFR3up-regulatesTCF4activatesR-3000-1.6876212Pr-105
KDM3Bdown-regulatesTCF4activatesR-3000-1.6876212Pr-105
t(11;14)down-regulatesTCF4activatesR-3000-1.6876212Pr-105
RNASeq_FGFR3_Callup-regulatesTCF4activatesR-3000-1.6876212Pr-105
t(4;14)up-regulatesTCF4activatesR-3000-1.6876212Pr-105
t(11;14)_cytogeneticdown-regulatesTCF4activatesR-3000-1.6876212Pr-105
t(4;14)_cytogeneticup-regulatesTCF4activatesR-3000-1.6876212Pr-105

Regulons in program Pr-105

Regulon Cox Hazard Ratio # genes # causal flows
R-10720.037646582
R-2880-0.549489293
R-821-0.988313203
R-1432-1.02184281
R-81-1.36714303
R-2380-1.4586484
R-582-1.65525153
R-3000-1.68762128

Genes in program Pr-105

EnsEMBL IdEntrez IdPreferred
ENSG00000175595 2072ERCC4
ENSG00000182054 3418IDH2
ENSG00000188033 57474ZNF490
ENSG00000188522 644815FAM83G
ENSG00000198363 444ASPH
ENSG00000198848
ENSG00000205436 91828EXOC3L4
ENSG00000211584 55652SLC48A1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions