Program

Causal Mechanistic Flows with regulons in program Pr-102

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)down-regulatesTP53activatesR-367-0.66178211Pr-102
DCHS1down-regulatesELF2repressesR-985-0.8753858Pr-102
FAT3down-regulatesELF2repressesR-985-0.8753858Pr-102
NEBdown-regulatesBCL6repressesR-553-0.9637057Pr-102
SYNE1down-regulatesBCL6repressesR-553-0.9637057Pr-102
del17down-regulatesBCL6repressesR-553-0.9637057Pr-102
t(14;16)_cytogeneticdown-regulatesBCL6repressesR-553-0.9637057Pr-102
DCHS1down-regulatesELF3repressesR-2155-0.9637057Pr-102
del17down-regulatesELF3repressesR-2155-0.9637057Pr-102
del1pup-regulatesELF3repressesR-2155-0.9637057Pr-102
MAXup-regulatesTCF3activatesR-2062-1.1703120Pr-102
RNASeq_MAFA_Calldown-regulatesTCF3activatesR-2062-1.1703120Pr-102
t(11;14)down-regulatesNR2F6activatesR-1380-1.337547Pr-102
DCHS1up-regulatesE2F2activatesR-2947-1.793047Pr-102
DNAH5up-regulatesE2F2activatesR-2947-1.793047Pr-102
FAT3up-regulatesE2F2activatesR-2947-1.793047Pr-102
MAXup-regulatesE2F2activatesR-2947-1.793047Pr-102
PTPRDup-regulatesE2F2activatesR-2947-1.793047Pr-102
t(11;14)down-regulatesARID3AactivatesR-1355-2.235736Pr-102
t(14;16)up-regulatesZNF410repressesR-1937-2.2780410Pr-102
amp1qup-regulatesZNF410repressesR-1937-2.2780410Pr-102
del13up-regulatesZNF410repressesR-1937-2.2780410Pr-102
del1pup-regulatesZNF410repressesR-1937-2.2780410Pr-102
t(4;14)up-regulatesXBP1activatesR-3060-2.380368Pr-102
del1pdown-regulatesXBP1activatesR-3060-2.380368Pr-102
DIS3up-regulatesELK4repressesR-769-3.009127Pr-102
RNASeq_MAFB_Callup-regulatesELK4repressesR-769-3.009127Pr-102
t(14;16)up-regulatesELK4repressesR-769-3.009127Pr-102
TRAF3up-regulatesELK4repressesR-769-3.009127Pr-102
TTNup-regulatesELK4repressesR-769-3.009127Pr-102
amp1qup-regulatesELK4repressesR-769-3.009127Pr-102
del13up-regulatesELK4repressesR-769-3.009127Pr-102
del1pup-regulatesELK4repressesR-769-3.009127Pr-102
FGFR3up-regulatesCREB3L2activatesR-522-3.418026Pr-102
RNASeq_FGFR3_Callup-regulatesCREB3L2activatesR-522-3.418026Pr-102
MYCdown-regulatesCREB3L2activatesR-522-3.418026Pr-102
t(4;14)up-regulatesCREB3L2activatesR-522-3.418026Pr-102
TTNdown-regulatesCREB3L2activatesR-522-3.418026Pr-102
DIS3up-regulatesNRF1repressesR-2706-4.2651810Pr-102
t(11;14)up-regulatesNRF1repressesR-2706-4.2651810Pr-102
t(14;16)up-regulatesNRF1repressesR-2706-4.2651810Pr-102
amp1qup-regulatesNRF1repressesR-2706-4.2651810Pr-102
del13up-regulatesNRF1repressesR-2706-4.2651810Pr-102

Regulons in program Pr-102

Regulon Cox Hazard Ratio # genes # causal flows
R-367-0.661782111
R-985-0.87538582
R-553-0.96370574
R-2155-0.96370573
R-2062-1.17031202
R-1380-1.3375471
R-2947-1.7930475
R-1355-2.2357361
R-1937-2.27804104
R-3060-2.3803682
R-769-3.0091278
R-522-3.4180265
R-2706-4.26518105

Genes in program Pr-102

EnsEMBL IdEntrez IdPreferred
ENSG00000183813 1233CCR4
ENSG00000186432 3840KPNA4
ENSG00000187556 342977NANOS3
ENSG00000187566 378884NHLRC1
ENSG00000196890 128312HIST3H2BB
ENSG00000198231 11325DDX42
ENSG00000214193 79729SH3D21
ENSG00000251247 25850ZNF345
ENSG00000254093 54984PINX1
ENSG00000260916 9236CCPG1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions