Program

Causal Mechanistic Flows with regulons in program Pr-10

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
LTBup-regulatesFOXJ1activatesR-1850-0.06018218Pr-10
CMYA5down-regulatesATF3activatesR-2412-0.1075236Pr-10
DIS3up-regulatesATF3activatesR-2412-0.1075236Pr-10
PTPRDdown-regulatesATF3activatesR-2412-0.1075236Pr-10
RNASeq_FGFR3_Callup-regulatesATF3activatesR-2412-0.1075236Pr-10
t(4;14)up-regulatesATF3activatesR-2412-0.1075236Pr-10
TP53down-regulatesATF3activatesR-2412-0.1075236Pr-10
CMYA5down-regulatesCREB1activatesR-276-0.7642276Pr-10
MXRA5down-regulatesCREB1activatesR-276-0.7642276Pr-10
t(14;16)up-regulatesCREB1activatesR-276-0.7642276Pr-10
amp1qup-regulatesCREB1activatesR-276-0.7642276Pr-10
del13up-regulatesCREB1activatesR-276-0.7642276Pr-10
AHNAK2down-regulatesBBXactivatesR-1536-0.8091517Pr-10
CMYA5down-regulatesBBXactivatesR-1536-0.8091517Pr-10
DNAH5down-regulatesBBXactivatesR-1536-0.8091517Pr-10
PKHD1L1down-regulatesBBXactivatesR-1536-0.8091517Pr-10
TP53down-regulatesBBXactivatesR-1536-0.8091517Pr-10
ABCA13down-regulatesRFX1activatesR-2572-1.037116Pr-10
AHNAK2down-regulatesRFX1activatesR-2572-1.037116Pr-10
CMYA5down-regulatesRFX1activatesR-2572-1.037116Pr-10
DNAH5down-regulatesRFX1activatesR-2572-1.037116Pr-10
FGFR3up-regulatesRFX1activatesR-2572-1.037116Pr-10
MACF1down-regulatesRFX1activatesR-2572-1.037116Pr-10
t(11;14)up-regulatesRFX1activatesR-2572-1.037116Pr-10
RNASeq_FGFR3_Callup-regulatesRFX1activatesR-2572-1.037116Pr-10
t(4;14)up-regulatesRFX1activatesR-2572-1.037116Pr-10
t(11;14)_cytogeneticup-regulatesRFX1activatesR-2572-1.037116Pr-10
t(4;14)_cytogeneticup-regulatesRFX1activatesR-2572-1.037116Pr-10
CSMD3up-regulatesCEBPZrepressesR-755-1.139667Pr-10
FAT3up-regulatesCEBPZrepressesR-755-1.139667Pr-10
MYCup-regulatesCEBPZrepressesR-755-1.139667Pr-10
DMDup-regulatesARID5AactivatesR-607-1.15378Pr-10
CMYA5down-regulatesNFATC1activatesR-2204-1.157997Pr-10
DNAH5down-regulatesNFATC1activatesR-2204-1.157997Pr-10
FAT3down-regulatesNFATC1activatesR-2204-1.157997Pr-10
IRF4up-regulatesNFATC1activatesR-2204-1.157997Pr-10
LRP2down-regulatesNFATC1activatesR-2204-1.157997Pr-10
PKHD1L1down-regulatesNFATC1activatesR-2204-1.157997Pr-10
t(11;14)up-regulatesNFATC1activatesR-2204-1.157997Pr-10
RNASeq_CCND3_Callup-regulatesNFATC1activatesR-2204-1.157997Pr-10
RNASeq_MAFA_Calldown-regulatesNFATC1activatesR-2204-1.157997Pr-10
t(11;14)_cytogeneticup-regulatesNFATC1activatesR-2204-1.157997Pr-10
AHNAK2up-regulatesARID3ArepressesR-1353-1.165237Pr-10
t(11;14)down-regulatesARID3ArepressesR-1353-1.165237Pr-10
RNASeq_MAFA_Callup-regulatesARID3ArepressesR-1353-1.165237Pr-10
AHNAK2down-regulatesRFX3activatesR-1673-1.172737Pr-10
CMYA5down-regulatesRFX3activatesR-1673-1.172737Pr-10
DNAH5down-regulatesRFX3activatesR-1673-1.172737Pr-10
FGFR3up-regulatesRFX3activatesR-1673-1.172737Pr-10
MYO10down-regulatesRFX3activatesR-1673-1.172737Pr-10
t(11;14)up-regulatesRFX3activatesR-1673-1.172737Pr-10
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-1673-1.172737Pr-10
t(4;14)up-regulatesRFX3activatesR-1673-1.172737Pr-10
TRAF3down-regulatesRFX3activatesR-1673-1.172737Pr-10
t(11;14)_cytogeneticup-regulatesRFX3activatesR-1673-1.172737Pr-10
AHNAK2down-regulatesRUNX3activatesR-903-1.185536Pr-10
FGFR3up-regulatesRUNX3activatesR-903-1.185536Pr-10
PCDH10down-regulatesRUNX3activatesR-903-1.185536Pr-10
t(11;14)up-regulatesRUNX3activatesR-903-1.185536Pr-10
RNASeq_FGFR3_Callup-regulatesRUNX3activatesR-903-1.185536Pr-10
t(11;14)_cytogeneticup-regulatesRUNX3activatesR-903-1.185536Pr-10
AHNAK2up-regulatesATF1repressesR-571-1.196066Pr-10
DNAH5up-regulatesATF1repressesR-571-1.196066Pr-10
MACF1up-regulatesATF1repressesR-571-1.196066Pr-10
PCDH10up-regulatesATF1repressesR-571-1.196066Pr-10
TP53up-regulatesATF1repressesR-571-1.196066Pr-10
CMYA5down-regulatesZNF219activatesR-2217-1.201376Pr-10
DIS3up-regulatesZNF219activatesR-2217-1.201376Pr-10
IRF4up-regulatesZNF219activatesR-2217-1.201376Pr-10
t(11;14)up-regulatesZNF219activatesR-2217-1.201376Pr-10
t(11;14)_cytogeneticup-regulatesZNF219activatesR-2217-1.201376Pr-10
AHNAK2down-regulatesSTAT4activatesR-2657-1.220957Pr-10
DNAH5down-regulatesSTAT4activatesR-2657-1.220957Pr-10
FGFR3up-regulatesSTAT4activatesR-2657-1.220957Pr-10
RNASeq_FGFR3_Callup-regulatesSTAT4activatesR-2657-1.220957Pr-10
t(4;14)up-regulatesSTAT4activatesR-2657-1.220957Pr-10
t(4;14)_cytogeneticup-regulatesSTAT4activatesR-2657-1.220957Pr-10
ABCA13down-regulatesFOXO3activatesR-2774-1.2235812Pr-10
RNASeq_MAFA_Calldown-regulatesFOXO3activatesR-2774-1.2235812Pr-10
AHNAK2down-regulatesCEBPGactivatesR-448-1.375618Pr-10
FAT3down-regulatesCEBPGactivatesR-448-1.375618Pr-10
MACF1down-regulatesCEBPGactivatesR-448-1.375618Pr-10
PCDH10down-regulatesCEBPGactivatesR-448-1.375618Pr-10
RNASeq_MAFA_Calldown-regulatesCEBPGactivatesR-448-1.375618Pr-10
TACC2down-regulatesCEBPGactivatesR-448-1.375618Pr-10
ABCA13down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
AHNAK2down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
BRAFup-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
CMYA5down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
DNAH5down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
t(11;14)up-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
RNASeq_MAFA_Calldown-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
t(4;14)up-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
TACC2down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
del17down-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
del17pdown-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-2892-1.4609713Pr-10
AHNAK2down-regulatesFOXK1activatesR-1205-1.4617110Pr-10
FAT3down-regulatesFOXK1activatesR-1205-1.4617110Pr-10
MACF1down-regulatesFOXK1activatesR-1205-1.4617110Pr-10
RNASeq_MAFA_Calldown-regulatesFOXK1activatesR-1205-1.4617110Pr-10
t(4;14)up-regulatesFOXK1activatesR-1205-1.4617110Pr-10
TACC2down-regulatesFOXK1activatesR-1205-1.4617110Pr-10
CSMD3up-regulatesCEBPZrepressesR-757-1.579186Pr-10
FAT3up-regulatesCEBPZrepressesR-757-1.579186Pr-10
LRP2up-regulatesCEBPZrepressesR-757-1.579186Pr-10
MACF1up-regulatesCEBPZrepressesR-757-1.579186Pr-10
t(11;14)down-regulatesCEBPZrepressesR-757-1.579186Pr-10
MYCup-regulatesCEBPZrepressesR-757-1.579186Pr-10
TACC2up-regulatesCEBPZrepressesR-757-1.579186Pr-10
AHNAK2down-regulatesSPDEFactivatesR-1976-1.622166Pr-10
TP53down-regulatesSPDEFactivatesR-1976-1.622166Pr-10
AHNAK2down-regulatesZFXactivatesR-1918-1.6276415Pr-10
FGFR3up-regulatesZFXactivatesR-1918-1.6276415Pr-10
t(11;14)up-regulatesZFXactivatesR-1918-1.6276415Pr-10
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-1918-1.6276415Pr-10
t(4;14)up-regulatesZFXactivatesR-1918-1.6276415Pr-10
TP53down-regulatesZFXactivatesR-1918-1.6276415Pr-10
CMYA5down-regulatesELF3activatesR-2149-1.6765412Pr-10
FAT3down-regulatesELF3activatesR-2149-1.6765412Pr-10
t(11;14)up-regulatesELF3activatesR-2149-1.6765412Pr-10
TACC2down-regulatesELF3activatesR-2149-1.6765412Pr-10
TP53down-regulatesELF3activatesR-2149-1.6765412Pr-10
del17down-regulatesELF3activatesR-2149-1.6765412Pr-10
del17pdown-regulatesELF3activatesR-2149-1.6765412Pr-10
AHNAK2down-regulatesZNF281activatesR-2491-1.684279Pr-10
CMYA5down-regulatesZNF281activatesR-2491-1.684279Pr-10
FAT3down-regulatesZNF281activatesR-2491-1.684279Pr-10
MACF1down-regulatesZNF281activatesR-2491-1.684279Pr-10
PCDH10down-regulatesZNF281activatesR-2491-1.684279Pr-10
t(11;14)up-regulatesZNF281activatesR-2491-1.684279Pr-10
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-2491-1.684279Pr-10
t(4;14)up-regulatesZNF281activatesR-2491-1.684279Pr-10
TACC2down-regulatesZNF281activatesR-2491-1.684279Pr-10
t(11;14)_cytogeneticup-regulatesZNF281activatesR-2491-1.684279Pr-10
AHNAK2down-regulatesRREB1activatesR-2302-1.953347Pr-10
CMYA5down-regulatesRREB1activatesR-2302-1.953347Pr-10
MACF1down-regulatesRREB1activatesR-2302-1.953347Pr-10
RNASeq_MAFA_Calldown-regulatesRREB1activatesR-2302-1.953347Pr-10
TACC2down-regulatesRREB1activatesR-2302-1.953347Pr-10
TP53down-regulatesRREB1activatesR-2302-1.953347Pr-10
AHNAK2down-regulatesCREB1activatesR-274-1.974157Pr-10
CMYA5down-regulatesCREB1activatesR-274-1.974157Pr-10
DNAH5down-regulatesCREB1activatesR-274-1.974157Pr-10
FAT3down-regulatesCREB1activatesR-274-1.974157Pr-10
PKHD1L1down-regulatesCREB1activatesR-274-1.974157Pr-10
TP53down-regulatesCREB1activatesR-274-1.974157Pr-10
CMYA5down-regulatesZBTB16activatesR-588-2.423139Pr-10
DNAH5down-regulatesZBTB16activatesR-588-2.423139Pr-10
t(11;14)up-regulatesZBTB16activatesR-588-2.423139Pr-10
t(11;14)_cytogeneticup-regulatesZBTB16activatesR-588-2.423139Pr-10
AHNAK2down-regulatesATF4activatesR-95-2.895046Pr-10
CMYA5down-regulatesATF4activatesR-95-2.895046Pr-10
KRASup-regulatesATF4activatesR-95-2.895046Pr-10
MYO10down-regulatesATF4activatesR-95-2.895046Pr-10
PCDH10down-regulatesATF4activatesR-95-2.895046Pr-10
t(11;14)up-regulatesATF4activatesR-95-2.895046Pr-10
RNASeq_MAFA_Calldown-regulatesATF4activatesR-95-2.895046Pr-10
t(4;14)up-regulatesATF4activatesR-95-2.895046Pr-10
SYNE1down-regulatesATF4activatesR-95-2.895046Pr-10
TP53down-regulatesATF4activatesR-95-2.895046Pr-10
t(11;14)_cytogeneticup-regulatesATF4activatesR-95-2.895046Pr-10
t(14;16)_cytogeneticdown-regulatesATF4activatesR-95-2.895046Pr-10

Regulons in program Pr-10

Regulon Cox Hazard Ratio # genes # causal flows
R-1850-0.060182181
R-2412-0.10752366
R-276-0.76422765
R-1536-0.80915175
R-2572-1.03711611
R-755-1.1396673
R-607-1.153781
R-2204-1.15799710
R-1353-1.1652373
R-1673-1.17273710
R-903-1.1855366
R-571-1.1960665
R-2217-1.2013765
R-2657-1.2209576
R-2774-1.22358122
R-448-1.3756186
R-2892-1.460971312
R-1205-1.46171106
R-757-1.5791867
R-1976-1.6221662
R-1918-1.62764156
R-2149-1.67654127
R-2491-1.68427910
R-2302-1.9533476
R-274-1.9741576
R-588-2.4231394
R-95-2.89504612

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions