Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation RNASeq_CCND2_Call

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
MEF2Adown-regulatesR-18760.111678Pr-137
FLI1down-regulatesR-790-0.135687Pr-137
FLI1down-regulatesR-7820.152239Pr-137
ZBTB16down-regulatesR-5890.185533Pr-125
NFKB1down-regulatesR-1579-0.260085Pr-137
DBPdown-regulatesR-2956-0.373848Pr-111
ETS1down-regulatesR-12-0.427939Pr-60
NFKB1down-regulatesR-1572-0.445091Pr-0
GABPB1down-regulatesR-1950-0.479384Pr-137
BBXdown-regulatesR-1534-0.482476Pr-9
MEF2Adown-regulatesR-18860.552959Pr-129
NR3C1down-regulatesR-31900.592808Pr-23
HSF1down-regulatesR-50-0.599033Pr-16
HSF1down-regulatesR-540.604731Pr-125
FOXJ1up-regulatesR-1852-0.672195Pr-94
BORCS8-MEF2Bup-regulatesR-959-0.721458Pr-58
CREB5down-regulatesR-772-0.748892Pr-0
HSF1down-regulatesR-51-0.803656Pr-19
HSF1down-regulatesR-52-0.875962Pr-9
ETS1down-regulatesR-4-0.886127Pr-9
ZBTB16down-regulatesR-577-0.900835Pr-0
ZBTB16down-regulatesR-585-0.901934Pr-0
ETS1down-regulatesR-14-0.914198Pr-35
BBXdown-regulatesR-15320.944278Pr-16
NFATC1down-regulatesR-22050.94749Pr-33
ETS1down-regulatesR-00.98535Pr-136
NFATC1down-regulatesR-2207-1.00385Pr-15
STAT4down-regulatesR-26471.03676Pr-85
CREB1down-regulatesR-273-1.05492Pr-9
NR3C1down-regulatesR-3185-1.06036Pr-0
TRAF4down-regulatesR-30341.06768Pr-124
ETS1down-regulatesR-131.07999Pr-93
GABPB1down-regulatesR-19551.09101Pr-72
ZNF691up-regulatesR-30111.09639Pr-138
NFATC1down-regulatesR-22061.13365Pr-0
SATB1down-regulatesR-10781.15122Pr-122
NR3C1down-regulatesR-31831.16931Pr-13
MEF2Adown-regulatesR-1878-1.24921Pr-9
FOXP1down-regulatesR-31281.29587Pr-16
MEF2Adown-regulatesR-18711.35384Pr-16
BORCS8-MEF2Bup-regulatesR-9611.38182Pr-62
NFKB1down-regulatesR-1583-1.38564Pr-9
SATB1down-regulatesR-10741.38828Pr-111
ETS1down-regulatesR-81.3888Pr-96
NFKB1down-regulatesR-1593-1.40749Pr-15
FLI1down-regulatesR-789-1.43137Pr-19
CREB1down-regulatesR-277-1.54447Pr-35
ZNF219up-regulatesR-2211-1.56166Pr-86
ETS1down-regulatesR-2-1.58579Pr-19
ETS1down-regulatesR-1-1.61913Pr-64
TEFup-regulatesR-2408-1.64644Pr-65
NFKB2down-regulatesR-2824-1.72295Pr-4
SATB1down-regulatesR-1075-1.88885Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

ETS1down-regulatesR-111.98573Pr-138
BBXdown-regulatesR-1537-2.08705Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

BARX2down-regulatesR-2912.13395Pr-137
NR3C1down-regulatesR-3195-2.141Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

ZNF219up-regulatesR-22122.14665Pr-139
FOXP1down-regulatesR-3124-2.15985Pr-17
TRAF4down-regulatesR-3035-2.1684Pr-17
ZNF219up-regulatesR-22192.18386Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

FLI1down-regulatesR-7842.19671Pr-137
YY1down-regulatesR-25222.27836Pr-16
GABPB1down-regulatesR-1957-2.2937Pr-118
RUNX2down-regulatesR-12832.3191Pr-123
NFKB1down-regulatesR-1573-2.35352Pr-4
BBXdown-regulatesR-15332.412Pr-137
DBPdown-regulatesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

MEF2Adown-regulatesR-1867-2.61348Pr-86
NFATC1down-regulatesR-2202-2.7244Pr-19
FLI1down-regulatesR-7952.77664Pr-50
ENSG00000177374down-regulatesR-2362-2.78315Pr-91
NFKB1down-regulatesR-1587-2.87374Pr-86
STAT5Bdown-regulatesR-23673.00488Pr-123
NFE2L2up-regulatesR-19133.00873Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

BORCS8-MEF2Bup-regulatesR-962-3.11327Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

NR2F6up-regulatesR-1377-3.229Pr-137
TEFup-regulatesR-2406-3.30554Pr-135
NR3C1down-regulatesR-31883.34354Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

IRF4down-regulatesR-493-3.47489Pr-35
VDRdown-regulatesR-1229-3.57357Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

STAT4down-regulatesR-26503.59414Pr-123
STAT4down-regulatesR-2655-3.72135Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

NR3C1down-regulatesR-3191-3.95197Pr-104
MEF2Adown-regulatesR-18804.46094Pr-128
STAT4down-regulatesR-26534.54157Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions