Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation KRAS

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
SMAD3down-regulatesR-2966-0.0660624Pr-85
IRF1up-regulatesR-180-0.0848453Pr-0
HSF2up-regulatesR-3159-0.213586Pr-85
FOXJ3up-regulatesR-28820.27442Pr-117
ETS1down-regulatesR-12-0.427939Pr-60
RUNX3up-regulatesR-9020.511566Pr-0
SMAD3down-regulatesR-2962-0.592902Pr-122
HSF2up-regulatesR-31670.645152Pr-3
MYBdown-regulatesR-6150.668149Pr-85
FOXJ3up-regulatesR-28890.679009Pr-23
ELF1up-regulatesR-2995-0.821049Pr-117
CEBPBup-regulatesR-1777-0.838666Pr-129
IRF1up-regulatesR-1820.909345Pr-124
ARID3Adown-regulatesR-13400.91304Pr-124
PAX5up-regulatesR-23740.983647Pr-85
ELF1up-regulatesR-29821.00653Pr-58
MYBdown-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

TRAF4up-regulatesR-30341.06768Pr-124
FOXJ3up-regulatesR-2871-1.14551Pr-58
PATZ1up-regulatesR-2195-1.15328Pr-58
ARID3Adown-regulatesR-1344-1.15545Pr-9
IRF1up-regulatesR-1941.26041Pr-3
ETS1down-regulatesR-101.31637Pr-109
STAT4up-regulatesR-2654-1.46619Pr-9
HSF2up-regulatesR-3166-1.48665Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

IRF1up-regulatesR-188-1.56891Pr-99
MYBdown-regulatesR-6171.6152Pr-87
RFX3up-regulatesR-16571.68517Pr-60
MYBdown-regulatesR-622-1.933Pr-85
SMAD3down-regulatesR-2967-1.98807Pr-139
E4F1up-regulatesR-3148-2.09252Pr-58
RUNX3up-regulatesR-8922.10284Pr-125
ZNF219up-regulatesR-22122.14665Pr-139
ZNF219up-regulatesR-22192.18386Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

ARID3Adown-regulatesR-13382.23222Pr-60
PATZ1up-regulatesR-21962.39409Pr-55
RUNX3up-regulatesR-8982.74094Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

ATF4up-regulatesR-95-2.89504Pr-10
IRF1up-regulatesR-1973.05156Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

RFX3up-regulatesR-16623.44658Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

BORCS8-MEF2Bup-regulatesR-9603.7679Pr-75
FOX3Adown-regulatesR-15143.87415Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ZNF219up-regulatesR-22144.26397Pr-63

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions