Mutation – Multiple Myeloma Network Portal

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation IRF4

Regulator	Role	Regulon	Cox Hazard Ratio (Regulon)	Transcriptional Programs
PAX6	down-regulates	R-1556	0.0296134	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
ZNF740	up-regulates	R-386	0.111482	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
XBP1	down-regulates	R-3054	0.128472	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
PLAG1	down-regulates	R-1522	0.140759	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
ENSG00000105991	down-regulates	R-228	-0.185488	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
SP1	up-regulates	R-2714	0.199684	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
THRA	up-regulates	R-62	0.204827	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
RARA	up-regulates	R-161	-0.215419	Pr-112 Genes (5) CD19, COMMD6, MRPL21, IPP, FAM228B Regulons (10) R-161, R-1838, R-3036, R-1491, R-2275, R-835, R-676, R-1746, R-592, R-1218
NF1	up-regulates	R-127	-0.22305	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
PEBP1	up-regulates	R-1756	-0.29837	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
CEBPB	up-regulates	R-1768	-0.337185	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
HMGA1	down-regulates	R-817	-0.342996	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
ENSG00000176887	up-regulates	R-1893	0.370377	Pr-128 Genes (4) C10orf67, CLK3, PSTK Regulons (11) R-1200, R-1893, R-2641, R-1739, R-1183, R-1246, R-3081, R-225, R-1880, R-1475, R-90
PAX6	down-regulates	R-1545	-0.374773	Pr-14 Genes (17) TMEM70, TUBB6, PNMA1, CASKIN2, ANXA2R, MLF1, ARID3B, SLC17A8, FZD2, PLAG1, SLC8A1, SEMA4B, NOXA1, AKR1C3, MPV17L2 Regulons (18) R-1002, R-1429, R-1659, R-894, R-77, R-1832, R-1545, R-184, R-2284, R-2223, R-2075, R-2878, R-2606, R-1398, R-2952, R-1932, R-3170, R-2014
HMBOX1	up-regulates	R-2382	0.378178	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
NF1	up-regulates	R-130	0.381224	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
CEBPB	up-regulates	R-1770	0.400611	Pr-99 Genes (28) GNG7, ZBTB34, APOBEC3B, PSMG4, HSF1, PRPF39, ARL15, CERKL, MSL1, ZNF79, PLXNB2, YTHDF2, TLK1, TSEN15, CAPZA2, FCGR3A, LIME1, SMIM5, C6orf47, DENND6B, LIN52, RBMXL1, EMP2, TMEM167B, ZSCAN31, CDRT4 Regulons (31) R-3174, R-453, R-1770, R-3083, R-1212, R-648, R-2506, R-2709, R-1696, R-2314, R-2642, R-587, R-492, R-1891, R-3063, R-640, R-2162, R-3070, R-1834, R-188, R-2140, R-2317, R-1435, R-3129, R-699, R-3090, R-650, R-1007, R-2844, R-2311, R-606
HMGA1	down-regulates	R-832	0.407077	Pr-119 Genes (4) GPBAR1, RHD, GMFB, C5AR1 Regulons (4) R-832, R-1181, R-58, R-164
ZBTB3	down-regulates	R-1275	-0.421961	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
HOXA5	down-regulates	R-22	-0.436928	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
PLAG1	down-regulates	R-1516	-0.4439	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
ETV2	down-regulates	R-1511	0.447542	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
ENSG00000175832	up-regulates	R-314	0.462821	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
SPDEF	down-regulates	R-1972	-0.517954	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
RFX3	up-regulates	R-1677	0.519248	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
HMBOX1	up-regulates	R-2379	-0.550956	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
ZBTB3	down-regulates	R-1270	0.603274	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
PLAG1	down-regulates	R-1520	-0.621542	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
RUNX3	up-regulates	R-901	-0.632441	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
NFYC	up-regulates	R-298	-0.660463	Pr-59 Genes (15) DRAP1, MRPS23, CBX6, NDUFA12, UBALD2, MUC1, PBX1, PRELP, CFD, MPZL1, TBC1D8, STK38L, PCDHGA5, POC1B-GALNT4 Regulons (18) R-3140, R-2080, R-298, R-786, R-619, R-1472, R-450, R-601, R-2301, R-1564, R-654, R-2795, R-2891, R-3058, R-2183, R-1508, R-2708, R-658
CEBPB	up-regulates	R-1767	-0.661208	Pr-4 Genes (37) B3GNT4, ZNF575, CRACR2B, ALS2CL, TCAIM, MED14, ADO, SFXN4, TM2D3, GAS2L1, EIF4EBP1, COL4A5, LRRK2, MXD3, ZBED8, CFAP97D1, WDR92, TMEM141, USP51, ZNF260, MTRNR2L8, CLLU1, CHURC1, CEP95, MRPL12, RPS10-NUDT3, YY1, BACH2, E2F2 Regulons (47) R-295, R-2879, R-2639, R-2318, R-3043, R-1908, R-1695, R-1554, R-2485, R-1767, R-777, R-443, R-1753, R-2114, R-1585, R-2824, R-1670, R-560, R-293, R-773, R-2432, R-270, R-2099, R-778, R-1778, R-1633, R-1277, R-1463, R-818, R-176, R-1573, R-1468, R-2599, R-2799, R-68, R-2950, R-2767, R-1174, R-990, R-2658, R-2221, R-2487, R-1684, R-3051, R-2813, R-1017, R-506
NFATC1	up-regulates	R-2197	0.666306	Pr-29 Genes (9) P2RY2, SAMD9L, TMEM187, TRAK1, ANKRD45, PTP4A2, ZNF565, C17orf51 Regulons (9) R-1401, R-1870, R-1733, R-80, R-2197, R-993, R-1308, R-2683, R-548
FOXJ1	down-regulates	R-1852	-0.672195	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
NFATC1	up-regulates	R-2201	-0.687031	Pr-120 Genes (9) ANKLE2, TMEM52, YOD1, ZNF443, CDCA2, SIVA1, PSMD13, CHAMP1 Regulons (9) R-2299, R-2503, R-2342, R-546, R-2201, R-1346, R-1651, R-792, R-2963
PEBP1	up-regulates	R-1757	-0.714169	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
BORCS8-MEF2B	up-regulates	R-959	-0.721458	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
HMBOX1	up-regulates	R-2378	-0.732226	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
POU2F2	down-regulates	R-2510	-0.785808	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
ENSG00000165066	up-regulates	R-3078	-0.791137	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
CEBPB	up-regulates	R-1777	-0.838666	Pr-129 Genes (12) DALRD3, CTNNBIP1, FAHD1, ZBTB2, SLC2A4, UBA7, KLHDC8B, BCDIN3D, FAM111B, MAN1A2, HYLS1, INF2 Regulons (12) R-356, R-1920, R-2758, R-2274, R-507, R-1886, R-1777, R-1479, R-1180, R-2321, R-756, R-1179
HOXA3	down-regulates	R-221	0.849107	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
ZBTB16	up-regulates	R-578	-0.879917	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
DBP	down-regulates	R-2953	0.918338	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
HOXA3	down-regulates	R-223	0.936261	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
NFATC1	up-regulates	R-2205	0.94749	Pr-33 Genes (6) ZNF620, IMPDH2, SLC35C1, TIGIT, AP2A2, C11orf96 Regulons (6) R-1415, R-2349, R-2893, R-2147, R-1014, R-2205
NF1	up-regulates	R-128	0.964935	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
HMBOX1	up-regulates	R-2383	-0.967695	Pr-114 Genes (3) PCGF5, SAMD11, KCTD21 Regulons (7) R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107
ENSG00000165066	up-regulates	R-3080	0.967824	Pr-131 Genes (6) UBE2G2, ERC2, SLC9A8, ZNF770, MGEA5, ZNF350 Regulons (6) R-2999, R-3080, R-706, R-1303, R-79, R-1387
FOXO3	down-regulates	R-2777	-0.982827	Pr-27 Genes (8) AGMO, CALHM6, NHLRC2, DNM3, ITSN1, PLPP6 Regulons (8) R-2493, R-2777, R-1790, R-2323, R-2279, R-2558, R-2815, R-3194
ESRRA	down-regulates	R-2738	0.991373	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
GABPA	down-regulates	R-1456	-1.00351	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
CEBPB	up-regulates	R-1769	1.04174	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
RARA	up-regulates	R-162	-1.0531	Pr-92 Genes (9) SVBP, AKAP5, SLC25A42, HDDC3, ZNRF1, ZNF197, TMEM222, FAM120AOS Regulons (9) R-670, R-1389, R-1063, R-2294, R-1012, R-1938, R-209, R-2697, R-162
ETV2	down-regulates	R-1509	1.05383	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
HMGA1	down-regulates	R-833	1.0818	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
SPDEF	down-regulates	R-1977	-1.08293	Pr-97 Genes (5) THAP5, HMGB1, KPNA5, ATG9A, GLI4 Regulons (5) R-2187, R-1977, R-1209, R-3026, R-2354
DBP	down-regulates	R-2952	1.09035	Pr-14 Genes (17) TMEM70, TUBB6, PNMA1, CASKIN2, ANXA2R, MLF1, ARID3B, SLC17A8, FZD2, PLAG1, SLC8A1, SEMA4B, NOXA1, AKR1C3, MPV17L2 Regulons (18) R-1002, R-1429, R-1659, R-894, R-77, R-1832, R-1545, R-184, R-2284, R-2223, R-2075, R-2878, R-2606, R-1398, R-2952, R-1932, R-3170, R-2014
ENSG00000168269	down-regulates	R-1563	1.10269	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
HINFP	down-regulates	R-2625	-1.11022	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
NFATC1	up-regulates	R-2206	1.13365	Pr-0 Genes (84) GPX2, BNIP3, METRNL, PUS1, SAMD12, CD163, SLC25A20, EFCAB13, EXOSC4, SAMD4B, CATSPERE, C14orf119, ARHGAP45, BBS12, EHMT1, SETD2, ZBTB20, RFX7, TSKU, SRPRA, SLC25A10, ASB7, UPP1, LIN9, CCR10, ZFP1, USP18, TNFAIP2, CDNF, SOCS1, METTL7A, PDE6G, SP1, P4HB, DRG1, CXorf38, MORF4L1, AIDA, WWOX, SAPCD2, PPP1CC, SPIN4, CXCR3, ZNF397, TPCN1, CMC1, GCNT1, FNBP1, RSBN1L, LOC100288637, TMPPE, ZC3H6, ZNF669, NANOS1, ALKBH2, JPT1, LIN54, HLA-DRB1, ZNF493, EPHB4, TRAPPC2B, SIAH1, ESRRG, TCF4, SERTAD1, ZNF398, ZNF257, ATG7, MPEG1, RPS4X, PNP, HMGN2, HIST2H2BF, COLQ, RPS29 Regulons (86) R-180, R-2076, R-2157, R-3164, R-3147, R-338, R-2156, R-2409, R-885, R-941, R-1192, R-556, R-3197, R-1572, R-999, R-636, R-902, R-2541, R-440, R-890, R-3175, R-767, R-1542, R-1336, R-2472, R-1698, R-2326, R-1906, R-269, R-772, R-647, R-3033, R-2100, R-2711, R-1394, R-3068, R-508, R-63, R-1916, R-1188, R-532, R-2135, R-997, R-1687, R-2951, R-1853, R-2220, R-577, R-585, R-2597, R-1021, R-3119, R-301, R-559, R-1560, R-175, R-2870, R-3015, R-66, R-595, R-3185, R-2905, R-433, R-290, R-381, R-2509, R-562, R-2798, R-2206, R-1418, R-60, R-3050, R-2073, R-611, R-2488, R-881, R-1095, R-2153, R-2553, R-2305, R-2656, R-1697, R-511, R-2185, R-1492, R-2555
MZF1	down-regulates	R-3016	1.15326	Pr-5 Genes (32) ZNF25, POLD4, CLK2, EPS8L2, PIDD1, JUN, AGTRAP, C2orf69, GRINA, PTPN11, PITPNB, DNAH14, C15orf41, KIF18B, DUSP28, CFAP126, ZFP62, MYO5A, FAM114A1, FAM118B, PIM3, ZNF627, TEX45, ITPRIPL1, MRPL53, TECPR1, RNPS1, CFAP44, ZNF726, EML6, LOC441155 Regulons (33) R-362, R-1924, R-1337, R-92, R-1207, R-3137, R-2527, R-2775, R-2562, R-1927, R-2749, R-2109, R-1198, R-1854, R-275, R-2883, R-3016, R-286, R-1350, R-2038, R-148, R-42, R-3198, R-2569, R-2282, R-581, R-590, R-2346, R-2265, R-2473, R-2377, R-2110, R-1385
PATZ1	up-regulates	R-2195	-1.15328	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
NFATC1	up-regulates	R-2204	-1.15799	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
CEBPB	up-regulates	R-1762	1.16852	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
ESRRA	down-regulates	R-2746	1.17735	Pr-72 Genes (3) ZNF250, ZNF625 Regulons (13) R-1955, R-2746, R-714, R-693, R-705, R-2703, R-2530, R-1020, R-554, R-1391, R-2710, R-1743, R-831
POU2F2	down-regulates	R-2515	1.18037	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
SMAD3	up-regulates	R-2961	1.18119	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
THRA	up-regulates	R-58	1.19237	Pr-119 Genes (4) GPBAR1, RHD, GMFB, C5AR1 Regulons (4) R-832, R-1181, R-58, R-164
RARA	up-regulates	R-157	1.1957	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
ZNF219	up-regulates	R-2217	-1.20137	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
HMGA1	down-regulates	R-836	-1.21151	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
ENSG00000165066	up-regulates	R-3076	-1.21549	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
HMGA1	down-regulates	R-827	-1.23916	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
RARA	up-regulates	R-164	1.24046	Pr-119 Genes (4) GPBAR1, RHD, GMFB, C5AR1 Regulons (4) R-832, R-1181, R-58, R-164
HMGA1	down-regulates	R-826	1.24266	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
ATF2	up-regulates	R-3092	1.26346	Pr-111 Genes (12) PARP10, ZHX2, DNHD1, MRPL54, BRI3BP, TET3, DNAJB13, CDC42SE1, RPL23A, WDHD1 Regulons (12) R-1273, R-1009, R-2956, R-2337, R-983, R-2356, R-711, R-299, R-1708, R-3092, R-2721, R-1074
KLF13	down-regulates	R-2041	-1.31925	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
GABPA	down-regulates	R-1455	1.3231	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
ZNF219	up-regulates	R-2216	1.32424	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
ATF2	up-regulates	R-3091	1.32566	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
IRF4	down-regulates	R-492	-1.32725	Pr-99 Genes (28) GNG7, ZBTB34, APOBEC3B, PSMG4, HSF1, PRPF39, ARL15, CERKL, MSL1, ZNF79, PLXNB2, YTHDF2, TLK1, TSEN15, CAPZA2, FCGR3A, LIME1, SMIM5, C6orf47, DENND6B, LIN52, RBMXL1, EMP2, TMEM167B, ZSCAN31, CDRT4 Regulons (31) R-3174, R-453, R-1770, R-3083, R-1212, R-648, R-2506, R-2709, R-1696, R-2314, R-2642, R-587, R-492, R-1891, R-3063, R-640, R-2162, R-3070, R-1834, R-188, R-2140, R-2317, R-1435, R-3129, R-699, R-3090, R-650, R-1007, R-2844, R-2311, R-606
HSF4	up-regulates	R-174	-1.34961	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
RARA	up-regulates	R-148	1.3622	Pr-5 Genes (32) ZNF25, POLD4, CLK2, EPS8L2, PIDD1, JUN, AGTRAP, C2orf69, GRINA, PTPN11, PITPNB, DNAH14, C15orf41, KIF18B, DUSP28, CFAP126, ZFP62, MYO5A, FAM114A1, FAM118B, PIM3, ZNF627, TEX45, ITPRIPL1, MRPL53, TECPR1, RNPS1, CFAP44, ZNF726, EML6, LOC441155 Regulons (33) R-362, R-1924, R-1337, R-92, R-1207, R-3137, R-2527, R-2775, R-2562, R-1927, R-2749, R-2109, R-1198, R-1854, R-275, R-2883, R-3016, R-286, R-1350, R-2038, R-148, R-42, R-3198, R-2569, R-2282, R-581, R-590, R-2346, R-2265, R-2473, R-2377, R-2110, R-1385
GRHL1	down-regulates	R-3145	-1.37724	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
POU2F2	down-regulates	R-2512	1.37817	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
ENSG00000176887	up-regulates	R-1891	-1.3829	Pr-99 Genes (28) GNG7, ZBTB34, APOBEC3B, PSMG4, HSF1, PRPF39, ARL15, CERKL, MSL1, ZNF79, PLXNB2, YTHDF2, TLK1, TSEN15, CAPZA2, FCGR3A, LIME1, SMIM5, C6orf47, DENND6B, LIN52, RBMXL1, EMP2, TMEM167B, ZSCAN31, CDRT4 Regulons (31) R-3174, R-453, R-1770, R-3083, R-1212, R-648, R-2506, R-2709, R-1696, R-2314, R-2642, R-587, R-492, R-1891, R-3063, R-640, R-2162, R-3070, R-1834, R-188, R-2140, R-2317, R-1435, R-3129, R-699, R-3090, R-650, R-1007, R-2844, R-2311, R-606
RARA	up-regulates	R-163	1.38439	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
NR2C2	down-regulates	R-1390	-1.41324	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
SP1	up-regulates	R-2718	1.4306	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
ZNF740	up-regulates	R-395	-1.44318	Pr-28 Genes (7) PLA2G6, SFT2D1, ARL2, SLC35F6, FXYD7, FAM200B Regulons (7) R-287, R-395, R-2698, R-3055, R-1202, R-1412, R-602
SMAD3	up-regulates	R-2963	1.44668	Pr-120 Genes (9) ANKLE2, TMEM52, YOD1, ZNF443, CDCA2, SIVA1, PSMD13, CHAMP1 Regulons (9) R-2299, R-2503, R-2342, R-546, R-2201, R-1346, R-1651, R-792, R-2963
HMBOX1	up-regulates	R-2380	-1.45864	Pr-105 Genes (8) ERCC4, IDH2, ZNF490, FAM83G, ASPH, EXOC3L4, SLC48A1 Regulons (8) R-1072, R-2880, R-821, R-1432, R-81, R-2380, R-582, R-3000
STAT5A	up-regulates	R-2162	-1.47979	Pr-99 Genes (28) GNG7, ZBTB34, APOBEC3B, PSMG4, HSF1, PRPF39, ARL15, CERKL, MSL1, ZNF79, PLXNB2, YTHDF2, TLK1, TSEN15, CAPZA2, FCGR3A, LIME1, SMIM5, C6orf47, DENND6B, LIN52, RBMXL1, EMP2, TMEM167B, ZSCAN31, CDRT4 Regulons (31) R-3174, R-453, R-1770, R-3083, R-1212, R-648, R-2506, R-2709, R-1696, R-2314, R-2642, R-587, R-492, R-1891, R-3063, R-640, R-2162, R-3070, R-1834, R-188, R-2140, R-2317, R-1435, R-3129, R-699, R-3090, R-650, R-1007, R-2844, R-2311, R-606
MZF1	down-regulates	R-3026	1.49051	Pr-97 Genes (5) THAP5, HMGB1, KPNA5, ATG9A, GLI4 Regulons (5) R-2187, R-1977, R-1209, R-3026, R-2354
HOXA3	down-regulates	R-227	1.49853	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
SRF	down-regulates	R-1784	1.54282	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
PAX6	down-regulates	R-1544	1.54726	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
ZBTB3	down-regulates	R-1271	1.5513	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
PAX5	up-regulates	R-2376	1.56155	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
SPDEF	down-regulates	R-1974	1.59808	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
MYB	up-regulates	R-617	1.6152	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
ENSG00000168269	down-regulates	R-1566	-1.63414	Pr-65 Genes (4) IKZF1, TMEM203, PRR13 Regulons (7) R-3065, R-1578, R-1566, R-2408, R-1969, R-3143, R-2273
HOXA3	down-regulates	R-224	-1.66402	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
RFX3	up-regulates	R-1657	1.68517	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
RARA	up-regulates	R-156	1.71471	Pr-16 Genes (20) NR2C2, LOC653513, C11orf54, ZNRF3, NSMCE3, LRRC70, TAF9B, B3GLCT, ZNF775, PPTC7, TRIM33, SIPA1L1, ZNF460, ZNF790, ZKSCAN8, CEP290, CIPC, GIMAP1, LILRA6, CHMP4A Regulons (20) R-383, R-191, R-50, R-872, R-1431, R-1919, R-1532, R-1546, R-2884, R-84, R-2290, R-666, R-1935, R-3128, R-1871, R-2949, R-2227, R-156, R-1279, R-2522
ESRRA	down-regulates	R-2741	1.72748	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
RFX7	down-regulates	R-2750	-1.73199	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
RARA	up-regulates	R-155	-1.76335	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
ENSG00000165066	up-regulates	R-3084	1.77633	Pr-137 Genes (22) KCNE3, SUGCT, SLC35A4, COX8A, PRR15, PFN4, FAM91A1, TMEM94, C14orf28, CMTR2, NQO1, FAM120C, PTPN1, SLC25A29, TMA16, MZT1, CSNK1E, KCTD7, CDK3, CHMP1B, COMMD3-BMI1 Regulons (23) R-2269, R-1302, R-186, R-1876, R-790, R-972, R-782, R-1579, R-1150, R-704, R-1950, R-1175, R-1457, R-1988, R-1345, R-713, R-3084, R-291, R-784, R-1348, R-2965, R-1533, R-1377
HMGA1	down-regulates	R-820	1.79517	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
ZBTB16	up-regulates	R-586	1.81277	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
ESRRA	down-regulates	R-2736	1.82545	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
SRF	down-regulates	R-1788	-1.83514	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
CEBPB	up-regulates	R-1763	-1.95423	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
SPDEF	down-regulates	R-1964	1.96106	Pr-127 Genes (11) KCNA3, GIMAP5, ZSCAN16, PSAP, FAM109A, SMURF1, GPATCH3, RPL10A Regulons (12) R-93, R-1513, R-1824, R-1762, R-3039, R-2608, R-1268, R-85, R-2718, R-1784, R-1964, R-2203
ZNF740	up-regulates	R-384	1.98118	Pr-52 Genes (3) LTN1, DHFR Regulons (14) R-2811, R-2250, R-384, R-1233, R-1661, R-2629, R-3077, R-1986, R-1548, R-305, R-2978, R-870, R-2716, R-496
SMAD3	up-regulates	R-2967	-1.98807	Pr-139 Genes (11) MRFAP1, PRKRA, BAZ1A, FAM72D, LHX4-AS1, ZNF709, TMEM35B, ATXN7L3B, NFIA Regulons (11) R-2364, R-2807, R-3003, R-3009, R-3093, R-2967, R-1776, R-2212, R-397, R-3022, R-1524
PLAG1	down-regulates	R-1521	-2.02883	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
RFX3	up-regulates	R-1675	2.03925	Pr-121 Genes (3) KPNA2, KIAA0040, ATP6V1E2 Regulons (3) R-1958, R-1675, R-996
PLAG1	down-regulates	R-1530	-2.05356	Pr-61 Genes (2) HLA-DQA1, SCARF2 Regulons (13) R-1530, R-2176, R-151, R-637, R-153, R-2896, R-612, R-909, R-2375, R-1414, R-2980, R-653, R-1529
NR3C1	down-regulates	R-3179	2.06628	Pr-60 Genes (13) MYLPF, CXCR2, SCRIB, RNF41, PPP1R27, FAM167B, SIGIRR, NOC2L, KLHL14, SELENOH, STARD10, TNFSF12, SELENOP Regulons (16) R-12, R-2753, R-314, R-2433, R-1411, R-2357, R-2343, R-1509, R-1392, R-1657, R-2736, R-3179, R-1338, R-1887, R-354, R-1354
E4F1	up-regulates	R-3148	-2.09252	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
PLAG1	down-regulates	R-1525	-2.09931	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
RUNX3	up-regulates	R-892	2.10284	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
XBP1	down-regulates	R-3062	-2.11726	Pr-25 Genes (9) RNPEP, RUFY1, ZNF664, TRNAU1AP, CLEC4G, SRC, HLA-F, RTL5 Regulons (9) R-974, R-1686, R-160, R-709, R-2312, R-2984, R-2341, R-2802, R-3062
CEBPB	up-regulates	R-1776	2.1174	Pr-139 Genes (11) MRFAP1, PRKRA, BAZ1A, FAM72D, LHX4-AS1, ZNF709, TMEM35B, ATXN7L3B, NFIA Regulons (11) R-2364, R-2807, R-3003, R-3009, R-3093, R-2967, R-1776, R-2212, R-397, R-3022, R-1524
ESRRA	down-regulates	R-2739	2.13083	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
NR3C1	down-regulates	R-3195	-2.141	Pr-116 Genes (3) CLCF1, RDH14 Regulons (3) R-1217, R-1537, R-3195
ESRRA	down-regulates	R-2744	2.16113	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
ZNF219	up-regulates	R-2219	2.18386	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
CEBPB	up-regulates	R-1766	-2.18542	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
FLI1	down-regulates	R-784	2.19671	Pr-137 Genes (22) KCNE3, SUGCT, SLC35A4, COX8A, PRR15, PFN4, FAM91A1, TMEM94, C14orf28, CMTR2, NQO1, FAM120C, PTPN1, SLC25A29, TMA16, MZT1, CSNK1E, KCTD7, CDK3, CHMP1B, COMMD3-BMI1 Regulons (23) R-2269, R-1302, R-186, R-1876, R-790, R-972, R-782, R-1579, R-1150, R-704, R-1950, R-1175, R-1457, R-1988, R-1345, R-713, R-3084, R-291, R-784, R-1348, R-2965, R-1533, R-1377
RFX3	up-regulates	R-1676	-2.24353	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
SPDEF	down-regulates	R-1967	-2.26981	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
SMAD3	up-regulates	R-2965	2.28284	Pr-137 Genes (22) KCNE3, SUGCT, SLC35A4, COX8A, PRR15, PFN4, FAM91A1, TMEM94, C14orf28, CMTR2, NQO1, FAM120C, PTPN1, SLC25A29, TMA16, MZT1, CSNK1E, KCTD7, CDK3, CHMP1B, COMMD3-BMI1 Regulons (23) R-2269, R-1302, R-186, R-1876, R-790, R-972, R-782, R-1579, R-1150, R-704, R-1950, R-1175, R-1457, R-1988, R-1345, R-713, R-3084, R-291, R-784, R-1348, R-2965, R-1533, R-1377
MZF1	down-regulates	R-3021	2.2875	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
HINFP	down-regulates	R-2628	-2.29875	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
HMGA1	down-regulates	R-834	2.30843	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
NR2C2	down-regulates	R-1387	2.31271	Pr-131 Genes (6) UBE2G2, ERC2, SLC9A8, ZNF770, MGEA5, ZNF350 Regulons (6) R-2999, R-3080, R-706, R-1303, R-79, R-1387
RUNX2	up-regulates	R-1283	2.3191	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
MZF1	down-regulates	R-3022	-2.32297	Pr-139 Genes (11) MRFAP1, PRKRA, BAZ1A, FAM72D, LHX4-AS1, ZNF709, TMEM35B, ATXN7L3B, NFIA Regulons (11) R-2364, R-2807, R-3003, R-3009, R-3093, R-2967, R-1776, R-2212, R-397, R-3022, R-1524
GABPA	down-regulates	R-1458	-2.32781	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
NR2F6	down-regulates	R-1375	2.34002	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
NR3C1	down-regulates	R-3187	-2.36326	Pr-85 Genes (18) A2M, ANAPC2, NIM1K, ZFAND2A, GCC1, ERCC6L2, UBE2E2, MTA1, TOB2, SNAI3, RINL, SMIM15, SULT1C2, SMG5, SYS1, CDPF1, SLC12A8, ITGB3 Regulons (21) R-2966, R-484, R-3159, R-597, R-661, R-1688, R-1272, R-2328, R-615, R-2366, R-2374, R-2647, R-360, R-977, R-3017, R-1311, R-622, R-3187, R-2071, R-3002, R-2492
RARA	up-regulates	R-167	-2.36681	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
XBP1	down-regulates	R-3056	-2.38499	Pr-107 Genes (3) HIST4H4, BRK1, OCLM Regulons (4) R-521, R-2523, R-3056, R-154
ZBTB16	up-regulates	R-593	2.41668	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
PAX6	down-regulates	R-1559	-2.4187	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
BARX2	down-regulates	R-292	-2.43197	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
SRF	down-regulates	R-1786	2.43898	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
RUNX3	up-regulates	R-897	2.4661	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
CEBPB	up-regulates	R-1760	2.49135	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
ENSG00000168269	down-regulates	R-1571	2.51736	Pr-136 Genes (30) TPRN, WRB, IFITM2, LILRA5, C2orf88, RILPL1, TUBB4B, KAZN, FAM72D, GAL3ST4, SREBF2, CENPW, SARNP, MFSD2B, FGFR1OP, GPC2, SRA1, LBH, FAM200A, OST4, KIFC1, APOPT1, S1PR2, FOXJ1, TGIF1 Regulons (34) R-1265, R-2164, R-193, R-3073, R-638, R-2640, R-2531, R-2238, R-331, R-0, R-339, R-2845, R-1902, R-2701, R-1452, R-702, R-695, R-2566, R-1421, R-2803, R-1827, R-2404, R-2705, R-1453, R-2266, R-87, R-834, R-779, R-1471, R-335, R-1571, R-970, R-2751, R-1629
SRF	down-regulates	R-1782	-2.52908	Pr-15 Genes (14) RBM33, RUFY4, SLC39A10, RPE, GLMP, MSRB1, BMPR2, SIPA1, VDAC1, EIF6, STON1, PRKDC Regulons (22) R-2088, R-2040, R-2207, R-282, R-2251, R-2946, R-1593, R-2737, R-1470, R-1848, R-1263, R-297, R-989, R-36, R-1782, R-1427, R-2049, R-2191, R-2288, R-1104, R-149, R-2959
ETV2	down-regulates	R-1510	-2.52918	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
SP1	up-regulates	R-2727	2.53149	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
SPDEF	down-regulates	R-1969	-2.53849	Pr-65 Genes (4) IKZF1, TMEM203, PRR13 Regulons (7) R-3065, R-1578, R-1566, R-2408, R-1969, R-3143, R-2273
BORCS8-MEF2B	up-regulates	R-963	2.55553	Pr-82 Genes (2) ZBED5 Regulons (3) R-2436, R-2560, R-963
ETV2	down-regulates	R-1508	2.5634	Pr-59 Genes (15) DRAP1, MRPS23, CBX6, NDUFA12, UBALD2, MUC1, PBX1, PRELP, CFD, MPZL1, TBC1D8, STK38L, PCDHGA5, POC1B-GALNT4 Regulons (18) R-3140, R-2080, R-298, R-786, R-619, R-1472, R-450, R-601, R-2301, R-1564, R-654, R-2795, R-2891, R-3058, R-2183, R-1508, R-2708, R-658
MZF1	down-regulates	R-3020	2.57034	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
PAX6	down-regulates	R-1547	2.58661	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
NR3C1	down-regulates	R-3196	-2.61331	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
ENSG00000176887	up-regulates	R-1898	-2.61611	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
RUNX2	up-regulates	R-1284	2.62887	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
HMGA1	down-regulates	R-830	-2.65695	Pr-109 Genes (12) MAN1B1, APOLD1, GEMIN4, GPR135, HIST2H2AB, MBP, ZXDB, FAM19A5, PPT2, DBNDD2, PGAM5, ETV6 Regulons (15) R-2714, R-1768, R-130, R-1972, R-2652, R-10, R-1079, R-1946, R-2505, R-2405, R-1478, R-1654, R-830, R-1773, R-170
RARA	up-regulates	R-158	-2.69255	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
BRCA1	up-regulates	R-1031	2.71498	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
FLI1	down-regulates	R-795	2.77664	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
PEBP1	up-regulates	R-1755	2.80711	Pr-1 Genes (49) TOMM5, CTDNEP1, GAPT, UBE2O, CSTF3, DNAJC30, WSB2, PXMP2, MAMSTR, SIX5, ACER2, CHD9, RABEP2, DHFR2, RMI1, TMTC2, EDC3, PCED1B, PIPOX, ZNF154, ZNF816, MOB2, AP1S2, ACBD3, ZNF721, SPATA13, GDPGP1, ZNF438, TSSC4, H1FX, SYN3, RASA3, ZNF17, NUDT17, MITF, FAM122A, BLOC1S2, HLA-DQA1, LRP10, PELI1, TAF13, TMEM116, ZDHHC18, DENND1B, CFAP45, NDUFS3, TNF, PPP1R3E Regulons (54) R-2690, R-2360, R-579, R-2136, R-271, R-279, R-891, R-1826, R-1172, R-1395, R-2327, R-662, R-1685, R-2872, R-2264, R-2635, R-533, R-596, R-882, R-2045, R-1190, R-69, R-2474, R-1543, R-2600, R-1419, R-434, R-561, R-359, R-3074, R-1103, R-3169, R-2542, R-774, R-1630, R-3176, R-998, R-1864, R-1959, R-2074, R-1789, R-302, R-1062, R-483, R-2249, R-1841, R-1925, R-447, R-2808, R-874, R-1755, R-393, R-988, R-1109
ETV2	down-regulates	R-1507	-2.80802	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
HSF4	up-regulates	R-173	2.83222	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
RFX3	up-regulates	R-1664	-2.83731	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
ZBTB16	up-regulates	R-584	-2.83773	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
NR3C1	down-regulates	R-3182	-2.83908	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
HOXA5	down-regulates	R-25	-2.84707	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
ENSG00000105991	down-regulates	R-229	-2.84707	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
HMGA1	down-regulates	R-835	-2.84969	Pr-112 Genes (5) CD19, COMMD6, MRPL21, IPP, FAM228B Regulons (10) R-161, R-1838, R-3036, R-1491, R-2275, R-835, R-676, R-1746, R-592, R-1218
ENSG00000175832	up-regulates	R-313	-2.85877	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
HMGA1	down-regulates	R-819	-2.87568	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
HOXA5	down-regulates	R-23	2.9056	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
RARA	up-regulates	R-154	-2.90748	Pr-107 Genes (3) HIST4H4, BRK1, OCLM Regulons (4) R-521, R-2523, R-3056, R-154
NR3C1	down-regulates	R-3186	-2.93135	Pr-91 Genes (10) ZNF667, DZIP3, TMX2, BBIP1, C19orf24, HLA-DPA1, SERPINB10, P2RY11, NFE2L1, IRF7 Regulons (12) R-1211, R-1821, R-1822, R-1580, R-824, R-1298, R-2056, R-896, R-2268, R-1085, R-2362, R-3186
HINFP	down-regulates	R-2621	-2.97505	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
FLI1	down-regulates	R-787	-3.00169	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
FOXJ1	down-regulates	R-1851	-3.04919	Pr-44 Genes (0) Regulons (7) R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280
FLI1	down-regulates	R-781	3.05111	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
SRF	down-regulates	R-1779	-3.05603	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
ENSG00000175832	up-regulates	R-312	-3.06	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
STAT5A	up-regulates	R-2161	-3.07199	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
STAT5A	up-regulates	R-2168	3.10259	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
ZNF219	up-regulates	R-2213	-3.11551	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
FLI1	down-regulates	R-780	-3.11957	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
HMBOX1	up-regulates	R-2381	3.13315	Pr-48 Genes (0) Regulons (17) R-1901, R-1219, R-1558, R-2381, R-1896, R-2829, R-667, R-871, R-76, R-498, R-2885, R-2549, R-2975, R-2078, R-2904, R-2152, R-2495
POU2F2	down-regulates	R-2519	-3.13355	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-616	3.1672	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
RARA	up-regulates	R-153	-3.1944	Pr-61 Genes (2) HLA-DQA1, SCARF2 Regulons (13) R-1530, R-2176, R-151, R-637, R-153, R-2896, R-612, R-909, R-2375, R-1414, R-2980, R-653, R-1529
ZBTB16	up-regulates	R-591	-3.27441	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
CEBPB	up-regulates	R-1761	-3.29826	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
FOXO3	down-regulates	R-2771	-3.30433	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ESRRA	down-regulates	R-2745	-3.32726	Pr-43 Genes (1) C14orf132 Regulons (3) R-3072, R-2745, R-608
ENSG00000165066	up-regulates	R-3082	3.32738	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
FOXO3	down-regulates	R-2773	-3.37313	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
MYB	up-regulates	R-620	-3.37541	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
PEBP1	up-regulates	R-1752	-3.39081	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
MZF1	down-regulates	R-3019	-3.42244	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
ENSG00000176887	up-regulates	R-1892	3.42989	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
RFX3	up-regulates	R-1662	3.44658	Pr-83 Genes (1) APOBEC3D Regulons (4) R-2101, R-2954, R-1662, R-2556
BRCA1	up-regulates	R-1030	-3.4552	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
ESRRA	down-regulates	R-2743	-3.48448	Pr-86 Genes (14) ARHGEF12, HTT, KTI12, MACO1, CCNI2, LEPROT, WBP1, JMJD7, ETV5, PCDHGA10, HSF4, TRIM28, MIXL1 Regulons (28) R-968, R-1987, R-3193, R-2211, R-379, R-2240, R-452, R-2649, R-1141, R-3044, R-2159, R-992, R-2877, R-1422, R-33, R-1867, R-2544, R-2050, R-1136, R-1587, R-2478, R-1576, R-2693, R-2605, R-2355, R-2743, R-2253, R-2270
NF1	up-regulates	R-124	-3.496	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
SPDEF	down-regulates	R-1973	3.49659	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
POU2F2	down-regulates	R-2511	-3.52119	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ZBTB3	down-regulates	R-1269	-3.55836	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
ENSG00000176887	up-regulates	R-1897	-3.60963	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
MZF1	down-regulates	R-3023	-3.63658	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
ENSG00000168269	down-regulates	R-1568	3.70657	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
ENSG00000176887	up-regulates	R-1895	3.70985	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
ENSG00000165066	up-regulates	R-3081	3.73477	Pr-128 Genes (4) C10orf67, CLK3, PSTK Regulons (11) R-1200, R-1893, R-2641, R-1739, R-1183, R-1246, R-3081, R-225, R-1880, R-1475, R-90
HOXA3	down-regulates	R-220	3.75971	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
CEBPB	up-regulates	R-1775	-3.79192	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
POU2F2	down-regulates	R-2520	-3.9229	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
CEBPB	up-regulates	R-1774	-3.92486	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
NR3C1	down-regulates	R-3191	-3.95197	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
SP1	up-regulates	R-2734	-3.98682	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
CEBPB	up-regulates	R-1772	4.02047	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
PAX5	up-regulates	R-2375	-4.04335	Pr-61 Genes (2) HLA-DQA1, SCARF2 Regulons (13) R-1530, R-2176, R-151, R-637, R-153, R-2896, R-612, R-909, R-2375, R-1414, R-2980, R-653, R-1529
HOXA3	down-regulates	R-225	4.12962	Pr-128 Genes (4) C10orf67, CLK3, PSTK Regulons (11) R-1200, R-1893, R-2641, R-1739, R-1183, R-1246, R-3081, R-225, R-1880, R-1475, R-90
SRF	down-regulates	R-1781	4.13916	Pr-70 Genes (1) SNURF Regulons (12) R-1694, R-505, R-1464, R-296, R-1781, R-2976, R-1469, R-73, R-942, R-1847, R-2281, R-2992
SPDEF	down-regulates	R-1963	-4.23229	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
MYB	up-regulates	R-626	-4.24578	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
ZNF219	up-regulates	R-2214	4.26397	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
SP1	up-regulates	R-2731	4.29242	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
NR2F6	down-regulates	R-1379	-4.31321	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
HMGA1	down-regulates	R-828	-4.34589	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
SP1	up-regulates	R-2735	-4.34716	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
NR2F6	down-regulates	R-1381	-4.38369	Pr-42 Genes (6) IRAK4, KLRK1, ANG, FNIP1, CD302, RAB44 Regulons (11) R-2041, R-155, R-2539, R-1503, R-1525, R-2628, R-2766, R-509, R-2700, R-2735, R-1381
FLI1	down-regulates	R-794	-4.49758	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
SRF	down-regulates	R-1785	4.55548	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
RARA	up-regulates	R-168	-4.56773	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
SP1	up-regulates	R-2722	4.57588	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
ESRRA	down-regulates	R-2740	-4.64571	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
RFX3	up-regulates	R-1671	4.70938	Pr-18 Genes (11) RPRM, FRAT2, SCFD2, PARPBP, ADAT2, INCA1, CASP4, DDRGK1, DDR1 Regulons (15) R-127, R-1406, R-1883, R-89, R-221, R-1440, R-604, R-2385, R-2515, R-1076, R-165, R-2899, R-2246, R-2731, R-1671
GRHL1	down-regulates	R-3146	-4.75189	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
ENSG00000168269	down-regulates	R-1567	-4.76751	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
ZNF219	up-regulates	R-2215	-4.80967	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
VDR	down-regulates	R-1231	5.12816	Pr-76 Genes (1) Regulons (7) R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024
POU2F2	down-regulates	R-2516	-5.21606	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
SREBF1	up-regulates	R-1138	-5.22607	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
SRF	down-regulates	R-1787	-5.29074	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-621	-5.47246	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
MYB	up-regulates	R-618	5.69454	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
SP1	up-regulates	R-2720	-6.02354	Pr-104 Genes (3) ZNF518B, POLR2M, MIA Regulons (12) R-374, R-1474, R-1081, R-2519, R-2496, R-3191, R-828, R-2215, R-1138, R-1787, R-621, R-2720
PLAG1	down-regulates	R-1523	-6.09323	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
FLI1	down-regulates	R-783	6.1459	Pr-69 Genes (1) KLF13 Regulons (9) R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719
SP1	up-regulates	R-2712	6.54886	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
RARA	up-regulates	R-152	6.62924	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
SP1	up-regulates	R-2719	6.73271	Pr-69 Genes (1) KLF13 Regulons (9) R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719
SRF	down-regulates	R-1780	7.20867	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
ENSG00000176399	up-regulates	R-1071	7.79759	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628

Causal Mechanistic Flows for Mutation IRF4

Genes (51)

Regulons (53)

Genes (28)

Regulons (28)

Genes (46)

Regulons (49)

Genes (9)

Regulons (9)

Genes (46)

Regulons (49)

Genes (12)

Regulons (15)

Genes (51)

Regulons (53)

Genes (5)

Regulons (10)

Genes (11)

Regulons (15)

Genes (28)

Regulons (28)

Genes (12)

Regulons (15)

Genes (28)

Regulons (28)

Genes (4)

Regulons (11)

Genes (17)

Regulons (18)

Genes (12)

Regulons (13)

Genes (12)

Regulons (15)

Genes (28)

Regulons (31)

Genes (4)

Regulons (4)

Genes (46)

Regulons (49)

Genes (46)

Regulons (49)

Genes (28)

Regulons (28)

Genes (12)

Regulons (13)

Genes (13)

Regulons (16)

Genes (12)

Regulons (15)

Genes (51)

Regulons (53)

Genes (46)

Regulons (49)

Genes (104)

Regulons (119)

Genes (46)

Regulons (49)

Genes (24)

Regulons (38)

Genes (15)

Regulons (18)

Genes (37)

Regulons (47)

Genes (9)

Regulons (9)

Genes (3)

Regulons (8)

Genes (9)

Regulons (9)

Genes (9)

Regulons (10)

Genes (28)

Regulons (28)

Genes (9)

Regulons (10)

Genes (28)

Regulons (28)

Genes (2)

Regulons (7)

Genes (12)