Program

Causal Mechanistic Flows with regulons in program Pr-108

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MAXup-regulatesXBP1activatesR-30520.55909917Pr-108
t(11;14)down-regulatesXBP1activatesR-30520.55909917Pr-108
MYCdown-regulatesXBP1activatesR-30520.55909917Pr-108
t(4;14)up-regulatesXBP1activatesR-30520.55909917Pr-108
t(11;14)_cytogeneticdown-regulatesXBP1activatesR-30520.55909917Pr-108
DIS3down-regulatesHINFPrepressesR-26260.7102386Pr-108
FGFR3down-regulatesHINFPrepressesR-26260.7102386Pr-108
NRASup-regulatesHINFPrepressesR-26260.7102386Pr-108
PRKD2down-regulatesHINFPrepressesR-26260.7102386Pr-108
t(11;14)down-regulatesHINFPrepressesR-26260.7102386Pr-108
RNASeq_FGFR3_Calldown-regulatesHINFPrepressesR-26260.7102386Pr-108
MYCup-regulatesHINFPrepressesR-26260.7102386Pr-108
t(4;14)down-regulatesHINFPrepressesR-26260.7102386Pr-108
del13down-regulatesHINFPrepressesR-26260.7102386Pr-108
t(4;14)_cytogeneticdown-regulatesHINFPrepressesR-26260.7102386Pr-108
DIS3down-regulatesPITX1repressesR-6600.9310277Pr-108
FAM46Cup-regulatesPITX1repressesR-6600.9310277Pr-108
FGFR3down-regulatesPITX1repressesR-6600.9310277Pr-108
NRASup-regulatesPITX1repressesR-6600.9310277Pr-108
t(11;14)down-regulatesPITX1repressesR-6600.9310277Pr-108
RNASeq_FGFR3_Calldown-regulatesPITX1repressesR-6600.9310277Pr-108
MYCup-regulatesPITX1repressesR-6600.9310277Pr-108
t(4;14)down-regulatesPITX1repressesR-6600.9310277Pr-108
del13down-regulatesPITX1repressesR-6600.9310277Pr-108
t(11;14)_cytogeneticdown-regulatesPITX1repressesR-6600.9310277Pr-108
t(4;14)_cytogeneticdown-regulatesPITX1repressesR-6600.9310277Pr-108
BAI3down-regulatesPLAG1activatesR-15171.2201625Pr-108
KDM3Bdown-regulatesPLAG1activatesR-15171.2201625Pr-108
t(11;14)down-regulatesPLAG1activatesR-15171.2201625Pr-108
RNASeq_MAFA_Calldown-regulatesPLAG1activatesR-15171.2201625Pr-108
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-15171.2201625Pr-108
FAT3up-regulatesRARBrepressesR-11061.295498Pr-108
FGFR3down-regulatesRARBrepressesR-11061.295498Pr-108
LRP1Bup-regulatesRARBrepressesR-11061.295498Pr-108
LTBdown-regulatesRARBrepressesR-11061.295498Pr-108
RNASeq_FGFR3_Calldown-regulatesRARBrepressesR-11061.295498Pr-108
MYCup-regulatesRARBrepressesR-11061.295498Pr-108
t(4;14)down-regulatesRARBrepressesR-11061.295498Pr-108
t(14;16)_cytogeneticup-regulatesRARBrepressesR-11061.295498Pr-108
t(4;14)_cytogeneticdown-regulatesRARBrepressesR-11061.295498Pr-108
DNAH10up-regulatesELF4activatesR-23391.8446818Pr-108
FGFR3up-regulatesELF4activatesR-23391.8446818Pr-108
KIAA1244down-regulatesELF4activatesR-23391.8446818Pr-108
PRKD2up-regulatesELF4activatesR-23391.8446818Pr-108
t(11;14)up-regulatesELF4activatesR-23391.8446818Pr-108
RNASeq_FGFR3_Callup-regulatesELF4activatesR-23391.8446818Pr-108
TRAF3down-regulatesELF4activatesR-23391.8446818Pr-108
CYLDup-regulatesMZF1repressesR-30271.863596Pr-108
DIS3down-regulatesMZF1repressesR-30271.863596Pr-108
DNAH10down-regulatesMZF1repressesR-30271.863596Pr-108
FGFR3down-regulatesMZF1repressesR-30271.863596Pr-108
LTBdown-regulatesMZF1repressesR-30271.863596Pr-108
MPDZup-regulatesMZF1repressesR-30271.863596Pr-108
NRASup-regulatesMZF1repressesR-30271.863596Pr-108
PRKD2down-regulatesMZF1repressesR-30271.863596Pr-108
RNASeq_FGFR3_Calldown-regulatesMZF1repressesR-30271.863596Pr-108
t(4;14)down-regulatesMZF1repressesR-30271.863596Pr-108
ROBO1up-regulatesMZF1repressesR-30271.863596Pr-108
amp1qdown-regulatesMZF1repressesR-30271.863596Pr-108
del13down-regulatesMZF1repressesR-30271.863596Pr-108
t(4;14)_cytogeneticdown-regulatesMZF1repressesR-30271.863596Pr-108
DNAH10up-regulatesIRF1activatesR-1962.0186416Pr-108
FGFR3up-regulatesIRF1activatesR-1962.0186416Pr-108
KIAA1244down-regulatesIRF1activatesR-1962.0186416Pr-108
PRKD2up-regulatesIRF1activatesR-1962.0186416Pr-108
t(11;14)up-regulatesIRF1activatesR-1962.0186416Pr-108
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-1962.0186416Pr-108
t(11;14)_cytogeneticup-regulatesIRF1activatesR-1962.0186416Pr-108
DNAH10up-regulatesRUNX3activatesR-8972.466110Pr-108
FGFR3up-regulatesRUNX3activatesR-8972.466110Pr-108
IRF4up-regulatesRUNX3activatesR-8972.466110Pr-108
KIAA1244down-regulatesRUNX3activatesR-8972.466110Pr-108
PRKD2up-regulatesRUNX3activatesR-8972.466110Pr-108
t(11;14)up-regulatesRUNX3activatesR-8972.466110Pr-108
RNASeq_FGFR3_Callup-regulatesRUNX3activatesR-8972.466110Pr-108
t(11;14)_cytogeneticup-regulatesRUNX3activatesR-8972.466110Pr-108
del13down-regulatesTRIM28repressesR-15022.594739Pr-108
MAGI1down-regulatesENSG00000165702activatesR-30882.620599Pr-108
MUC16down-regulatesENSG00000165702activatesR-30882.620599Pr-108
PTPRDdown-regulatesENSG00000165702activatesR-30882.620599Pr-108
MYCdown-regulatesENSG00000165702activatesR-30882.620599Pr-108
t(14;16)_cytogeneticdown-regulatesENSG00000165702activatesR-30882.620599Pr-108
COL6A5down-regulatesRUNX2activatesR-12842.628879Pr-108
DIS3up-regulatesRUNX2activatesR-12842.628879Pr-108
DNAH10up-regulatesRUNX2activatesR-12842.628879Pr-108
FGFR3up-regulatesRUNX2activatesR-12842.628879Pr-108
IRF4up-regulatesRUNX2activatesR-12842.628879Pr-108
KIAA1244down-regulatesRUNX2activatesR-12842.628879Pr-108
LTBup-regulatesRUNX2activatesR-12842.628879Pr-108
MYO10down-regulatesRUNX2activatesR-12842.628879Pr-108
PRKD2up-regulatesRUNX2activatesR-12842.628879Pr-108
t(11;14)up-regulatesRUNX2activatesR-12842.628879Pr-108
RNASeq_FGFR3_Callup-regulatesRUNX2activatesR-12842.628879Pr-108
t(4;14)up-regulatesRUNX2activatesR-12842.628879Pr-108
RYR2down-regulatesRUNX2activatesR-12842.628879Pr-108
t(11;14)_cytogeneticup-regulatesRUNX2activatesR-12842.628879Pr-108
t(14;16)_cytogeneticdown-regulatesRUNX2activatesR-12842.628879Pr-108
t(4;14)_cytogeneticup-regulatesRUNX2activatesR-12842.628879Pr-108
BAI3down-regulatesPLAG1activatesR-15182.6648217Pr-108
KDM3Bdown-regulatesPLAG1activatesR-15182.6648217Pr-108
t(11;14)down-regulatesPLAG1activatesR-15182.6648217Pr-108
RNASeq_MAFA_Calldown-regulatesPLAG1activatesR-15182.6648217Pr-108
t(14;16)down-regulatesPLAG1activatesR-15182.6648217Pr-108
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-15182.6648217Pr-108
KDM3Bdown-regulatesPLAG1activatesR-15192.7333415Pr-108
RNASeq_MAFA_Calldown-regulatesPLAG1activatesR-15192.7333415Pr-108
t(14;16)down-regulatesPLAG1activatesR-15192.7333415Pr-108
t(14;16)_cytogeneticdown-regulatesPLAG1activatesR-15192.7333415Pr-108
MAXdown-regulatesZNF740repressesR-3822.7373916Pr-108
RNASeq_FGFR3_Calldown-regulatesZNF740repressesR-3822.7373916Pr-108
t(4;14)down-regulatesZNF740repressesR-3822.7373916Pr-108
amp1qdown-regulatesZNF740repressesR-3822.7373916Pr-108
del13down-regulatesZNF740repressesR-3822.7373916Pr-108
t(4;14)_cytogeneticdown-regulatesZNF740repressesR-3822.7373916Pr-108
MAGI1down-regulatesARID5AactivatesR-6092.814386Pr-108
amp1qup-regulatesARID5AactivatesR-6092.814386Pr-108
del13up-regulatesARID5AactivatesR-6092.814386Pr-108
DIS3up-regulatesMEF2DactivatesR-8682.9277417Pr-108
FGFR3up-regulatesMEF2DactivatesR-8682.9277417Pr-108
LTBup-regulatesMEF2DactivatesR-8682.9277417Pr-108
t(11;14)down-regulatesMEF2DactivatesR-8682.9277417Pr-108
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8682.9277417Pr-108
t(4;14)up-regulatesMEF2DactivatesR-8682.9277417Pr-108
amp1qup-regulatesMEF2DactivatesR-8682.9277417Pr-108
del13up-regulatesMEF2DactivatesR-8682.9277417Pr-108
t(11;14)_cytogeneticdown-regulatesMEF2DactivatesR-8682.9277417Pr-108
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8682.9277417Pr-108
BAI3down-regulatesSOX4activatesR-21772.9386227Pr-108
CSMD1down-regulatesSOX4activatesR-21772.9386227Pr-108
CYLDdown-regulatesSOX4activatesR-21772.9386227Pr-108
DSTdown-regulatesSOX4activatesR-21772.9386227Pr-108
DUSP2down-regulatesSOX4activatesR-21772.9386227Pr-108
EYSdown-regulatesSOX4activatesR-21772.9386227Pr-108
FGFR3up-regulatesSOX4activatesR-21772.9386227Pr-108
GPR98down-regulatesSOX4activatesR-21772.9386227Pr-108
KDM3Bdown-regulatesSOX4activatesR-21772.9386227Pr-108
KMT2Bdown-regulatesSOX4activatesR-21772.9386227Pr-108
LTBup-regulatesSOX4activatesR-21772.9386227Pr-108
NRASdown-regulatesSOX4activatesR-21772.9386227Pr-108
PRKD2up-regulatesSOX4activatesR-21772.9386227Pr-108
t(11;14)down-regulatesSOX4activatesR-21772.9386227Pr-108
RNASeq_FGFR3_Callup-regulatesSOX4activatesR-21772.9386227Pr-108
RNASeq_MAFA_Calldown-regulatesSOX4activatesR-21772.9386227Pr-108
RNASeq_MAFB_Calldown-regulatesSOX4activatesR-21772.9386227Pr-108
t(14;16)down-regulatesSOX4activatesR-21772.9386227Pr-108
t(4;14)up-regulatesSOX4activatesR-21772.9386227Pr-108
RYR1down-regulatesSOX4activatesR-21772.9386227Pr-108
SDK1down-regulatesSOX4activatesR-21772.9386227Pr-108
del13up-regulatesSOX4activatesR-21772.9386227Pr-108
t(11;14)_cytogeneticdown-regulatesSOX4activatesR-21772.9386227Pr-108
t(4;14)_cytogeneticup-regulatesSOX4activatesR-21772.9386227Pr-108
t(4;14)up-regulatesFOXJ2activatesR-14243.0446633Pr-108
amp1qup-regulatesFOXJ2activatesR-14243.0446633Pr-108
del13up-regulatesFOXJ2activatesR-14243.0446633Pr-108
DIS3up-regulatesMEF2DactivatesR-8753.048478Pr-108
FGFR3up-regulatesMEF2DactivatesR-8753.048478Pr-108
LTBup-regulatesMEF2DactivatesR-8753.048478Pr-108
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8753.048478Pr-108
t(4;14)up-regulatesMEF2DactivatesR-8753.048478Pr-108
amp1qup-regulatesMEF2DactivatesR-8753.048478Pr-108
del13up-regulatesMEF2DactivatesR-8753.048478Pr-108
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8753.048478Pr-108
PTPRDdown-regulatesZNF281activatesR-24753.2136930Pr-108
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-24753.2136930Pr-108
t(4;14)up-regulatesZNF281activatesR-24753.2136930Pr-108
amp1qup-regulatesZNF281activatesR-24753.2136930Pr-108
del13up-regulatesZNF281activatesR-24753.2136930Pr-108
CYLDdown-regulatesENSG00000128652activatesR-22593.2233413Pr-108
DIS3up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
FAT1up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
FGFR3up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
GPR98down-regulatesENSG00000128652activatesR-22593.2233413Pr-108
MAXup-regulatesENSG00000128652activatesR-22593.2233413Pr-108
MUC16down-regulatesENSG00000128652activatesR-22593.2233413Pr-108
MYH2down-regulatesENSG00000128652activatesR-22593.2233413Pr-108
NRASdown-regulatesENSG00000128652activatesR-22593.2233413Pr-108
PRKD2up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
RNASeq_FGFR3_Callup-regulatesENSG00000128652activatesR-22593.2233413Pr-108
MYCdown-regulatesENSG00000128652activatesR-22593.2233413Pr-108
t(4;14)up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
amp1qup-regulatesENSG00000128652activatesR-22593.2233413Pr-108
del13up-regulatesENSG00000128652activatesR-22593.2233413Pr-108
t(4;14)_cytogeneticup-regulatesENSG00000128652activatesR-22593.2233413Pr-108
DIS3up-regulatesHOXD1activatesR-13013.243329Pr-108
DUSP2down-regulatesHOXD1activatesR-13013.243329Pr-108
FAT1up-regulatesHOXD1activatesR-13013.243329Pr-108
FGFR3up-regulatesHOXD1activatesR-13013.243329Pr-108
GPR98down-regulatesHOXD1activatesR-13013.243329Pr-108
KDM3Bdown-regulatesHOXD1activatesR-13013.243329Pr-108
LTBup-regulatesHOXD1activatesR-13013.243329Pr-108
MYH2down-regulatesHOXD1activatesR-13013.243329Pr-108
NRASdown-regulatesHOXD1activatesR-13013.243329Pr-108
PRKD2up-regulatesHOXD1activatesR-13013.243329Pr-108
RNASeq_FGFR3_Callup-regulatesHOXD1activatesR-13013.243329Pr-108
MYCdown-regulatesHOXD1activatesR-13013.243329Pr-108
t(4;14)up-regulatesHOXD1activatesR-13013.243329Pr-108
del13up-regulatesHOXD1activatesR-13013.243329Pr-108
del1pup-regulatesHOXD1activatesR-13013.243329Pr-108
t(4;14)_cytogeneticup-regulatesHOXD1activatesR-13013.243329Pr-108
BAI3down-regulatesPBX1activatesR-21053.2450920Pr-108
CYLDdown-regulatesPBX1activatesR-21053.2450920Pr-108
DIS3up-regulatesPBX1activatesR-21053.2450920Pr-108
DUSP2down-regulatesPBX1activatesR-21053.2450920Pr-108
FGFR3up-regulatesPBX1activatesR-21053.2450920Pr-108
GPR98down-regulatesPBX1activatesR-21053.2450920Pr-108
KDM3Bdown-regulatesPBX1activatesR-21053.2450920Pr-108
LTBup-regulatesPBX1activatesR-21053.2450920Pr-108
MUC16down-regulatesPBX1activatesR-21053.2450920Pr-108
MYH2down-regulatesPBX1activatesR-21053.2450920Pr-108
NRASdown-regulatesPBX1activatesR-21053.2450920Pr-108
PRKD2up-regulatesPBX1activatesR-21053.2450920Pr-108
PTPRDdown-regulatesPBX1activatesR-21053.2450920Pr-108
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21053.2450920Pr-108
MYCdown-regulatesPBX1activatesR-21053.2450920Pr-108
t(4;14)up-regulatesPBX1activatesR-21053.2450920Pr-108
RYR1down-regulatesPBX1activatesR-21053.2450920Pr-108
amp1qup-regulatesPBX1activatesR-21053.2450920Pr-108
del13up-regulatesPBX1activatesR-21053.2450920Pr-108
t(4;14)_cytogeneticup-regulatesPBX1activatesR-21053.2450920Pr-108
DIS3up-regulatesSP1activatesR-27293.2486915Pr-108
FGFR3up-regulatesSP1activatesR-27293.2486915Pr-108
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27293.2486915Pr-108
t(4;14)up-regulatesSP1activatesR-27293.2486915Pr-108
amp1qup-regulatesSP1activatesR-27293.2486915Pr-108
t(4;14)_cytogeneticup-regulatesSP1activatesR-27293.2486915Pr-108
COL6A5down-regulatesENSG00000179348activatesR-10553.2575519Pr-108
del1pup-regulatesENSG00000179348activatesR-10553.2575519Pr-108
CYLDdown-regulatesENSG00000128652activatesR-22623.310576Pr-108
FAT1up-regulatesENSG00000128652activatesR-22623.310576Pr-108
FGFR3up-regulatesENSG00000128652activatesR-22623.310576Pr-108
MAXup-regulatesENSG00000128652activatesR-22623.310576Pr-108
MUC16down-regulatesENSG00000128652activatesR-22623.310576Pr-108
NRASdown-regulatesENSG00000128652activatesR-22623.310576Pr-108
PRKD2up-regulatesENSG00000128652activatesR-22623.310576Pr-108
RNASeq_FGFR3_Callup-regulatesENSG00000128652activatesR-22623.310576Pr-108
t(4;14)up-regulatesENSG00000128652activatesR-22623.310576Pr-108
ROBO1down-regulatesENSG00000128652activatesR-22623.310576Pr-108
del13up-regulatesENSG00000128652activatesR-22623.310576Pr-108
t(4;14)_cytogeneticup-regulatesENSG00000128652activatesR-22623.310576Pr-108
CSMD1down-regulatesTEAD1activatesR-12143.3107520Pr-108
CYLDdown-regulatesTEAD1activatesR-12143.3107520Pr-108
DIS3up-regulatesTEAD1activatesR-12143.3107520Pr-108
DSTdown-regulatesTEAD1activatesR-12143.3107520Pr-108