Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation AHNAK2

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
IRF1down-regulatesR-177-0.0462797Pr-11
FOXP1down-regulatesR-31340.0646792Pr-56
RORAdown-regulatesR-2267-0.0655424Pr-2
TRAF4down-regulatesR-3037-0.0698997Pr-2
FOXJ2down-regulatesR-14290.070253Pr-14
DDIT3down-regulatesR-486-0.0796563Pr-2
IRF1down-regulatesR-180-0.0848453Pr-0
NRF1down-regulatesR-2707-0.0919786Pr-117
IRF1down-regulatesR-1860.0932494Pr-137
SP1up-regulatesR-2717-0.0948824Pr-2
FOXO1down-regulatesR-14000.106473Pr-124
MEF2Adown-regulatesR-18760.111678Pr-137
ELF2down-regulatesR-9740.122498Pr-25
MAFKdown-regulatesR-28110.123571Pr-52
RFX3down-regulatesR-16660.128531Pr-138
ARID3Aup-regulatesR-13370.134253Pr-5
FOXJ3down-regulatesR-28790.135462Pr-4
FLI1down-regulatesR-790-0.135687Pr-137
ATF3down-regulatesR-2410-0.14054Pr-3
ELF2down-regulatesR-972-0.144871Pr-137
FLI1down-regulatesR-7820.152239Pr-137
VBP1up-regulatesR-2104-0.154186Pr-2
RFX3down-regulatesR-16590.15727Pr-14
ZSCAN16up-regulatesR-631-0.165596Pr-2
NR3C1down-regulatesR-3178-0.173046Pr-2
ATF4down-regulatesR-920.179335Pr-5
NR3C1down-regulatesR-3177-0.1813Pr-6
E4F1down-regulatesR-3147-0.190868Pr-0
RUNX3down-regulatesR-894-0.20148Pr-14
HSF2down-regulatesR-3159-0.213586Pr-85
ATF1up-regulatesR-5630.219335Pr-2
FOXK1down-regulatesR-1207-0.237776Pr-5
FOXP1down-regulatesR-31370.242409Pr-5
CEBPGdown-regulatesR-436-0.258645Pr-2
POU2F1down-regulatesR-77-0.259838Pr-14
NFKB1down-regulatesR-1579-0.260085Pr-137
IRF1down-regulatesR-183-0.261893Pr-2
ELF1down-regulatesR-2977-0.272173Pr-2
POU2F1down-regulatesR-78-0.272418Pr-2
FOXJ2down-regulatesR-14250.273367Pr-124
HBP1down-regulatesR-18320.278908Pr-14
IRF1down-regulatesR-1910.280655Pr-16
FOXJ3down-regulatesR-2876-0.290335Pr-3
ELF1down-regulatesR-2979-0.300753Pr-64
ATF3down-regulatesR-2409-0.31315Pr-0
SF1down-regulatesR-1907-0.317014Pr-3
FOXK1down-regulatesR-1191-0.320198Pr-3
SPDEFdown-regulatesR-19620.33001Pr-124
RARAdown-regulatesR-160-0.331894Pr-25
ZNF281down-regulatesR-2479-0.333368Pr-2
ATF3down-regulatesR-24110.339529Pr-2
PARP1up-regulatesR-26370.341341Pr-24
ERFdown-regulatesR-3360.343262Pr-35
HBP1down-regulatesR-18280.348637Pr-124
HSF1down-regulatesR-49-0.350252Pr-2
FOXK1down-regulatesR-12000.353655Pr-128
FOXK1down-regulatesR-1192-0.353736Pr-0
TRAF4down-regulatesR-3043-0.355413Pr-4
CREB1down-regulatesR-2720.366974Pr-2
ZFXdown-regulatesR-1927-0.36742Pr-5
TFE3down-regulatesR-556-0.378688Pr-0
IRF9down-regulatesR-11500.383946Pr-137
IRF1down-regulatesR-184-0.386169Pr-14
CEBPGdown-regulatesR-4510.388628Pr-117
MEF2Adown-regulatesR-1869-0.397022Pr-2
HBP1down-regulatesR-1831-0.397545Pr-2
ETV6down-regulatesR-7000.401784Pr-24
MLXup-regulatesR-3197-0.407624Pr-0
FOXP1down-regulatesR-3121-0.417258Pr-3
ZBTB3up-regulatesR-1275-0.421961Pr-3
RREB1down-regulatesR-2284-0.436433Pr-14
NFKB1down-regulatesR-1572-0.445091Pr-0
HINFPdown-regulatesR-2624-0.44835Pr-35
ELF4down-regulatesR-2342-0.451214Pr-120
FOXK1down-regulatesR-1212-0.459405Pr-99
FOXP1down-regulatesR-3120-0.467693Pr-6
ETV6down-regulatesR-7040.469439Pr-137
BBXdown-regulatesR-1534-0.482476Pr-9
RFX3down-regulatesR-1660-0.495816Pr-2
CEBPGdown-regulatesR-435-0.497945Pr-6
RUNX3down-regulatesR-9020.511566Pr-0
MEF2Adown-regulatesR-1866-0.518528Pr-3
EWSR1down-regulatesR-2541-0.524632Pr-0
ELF4down-regulatesR-23440.524718Pr-23
CEBPGdown-regulatesR-440-0.532761Pr-0
EP300down-regulatesR-24330.537146Pr-60
RREB1down-regulatesR-2285-0.538758Pr-3
NFKB1down-regulatesR-1574-0.538784Pr-2
FOXO1down-regulatesR-1417-0.539502Pr-3
SPDEFdown-regulatesR-1960-0.548684Pr-3
FOXP1down-regulatesR-3126-0.555658Pr-2
ZBTB3up-regulatesR-1272-0.568661Pr-85
IKZF1down-regulatesR-9910.573701Pr-124
GABPB1down-regulatesR-19480.575567Pr-35
ELF1down-regulatesR-2984-0.581395Pr-25
FOXO1down-regulatesR-14110.58467Pr-60
NR4A2down-regulatesR-1717-0.584893Pr-2
RUNX3down-regulatesR-890-0.585918Pr-0
POU2F1down-regulatesR-71-0.58757Pr-3
FOXJ3down-regulatesR-2881-0.590232Pr-34
HSF1down-regulatesR-50-0.599033Pr-16
NR3C1down-regulatesR-3175-0.602124Pr-0
MEF2Adown-regulatesR-1865-0.617403Pr-6
RREB1down-regulatesR-2283-0.618728Pr-2
ARID3Aup-regulatesR-1341-0.641665Pr-2
ZNF281down-regulatesR-2485-0.64174Pr-4
SMAD4down-regulatesR-2357-0.642425Pr-60
RREB1down-regulatesR-2300-0.646333Pr-20
ETV3down-regulatesR-25350.649252Pr-117
ARID3Aup-regulatesR-1336-0.651462Pr-0
FOXJ3down-regulatesR-2878-0.651802Pr-14
EWSR1down-regulatesR-25590.652492Pr-125
ZNF281down-regulatesR-2472-0.661858Pr-0
MYBup-regulatesR-6150.668149Pr-85
IRF7down-regulatesR-10830.674001Pr-124
FOXJ3down-regulatesR-28890.679009Pr-23
NFKB1down-regulatesR-15770.685997Pr-124
POU2F1down-regulatesR-720.691442Pr-124
ELF4down-regulatesR-2326-0.702764Pr-0
SF1down-regulatesR-1906-0.707536Pr-0
FOXJ2down-regulatesR-1420-0.718874Pr-6
CREB1down-regulatesR-269-0.734328Pr-0
RREB1down-regulatesR-2296-0.757232Pr-9
MAZup-regulatesR-5000.764562Pr-117
FOXJ2down-regulatesR-14310.765091Pr-16
MYBup-regulatesR-619-0.781425Pr-59
TRAF4down-regulatesR-3033-0.781484Pr-0
NRF1down-regulatesR-2709-0.785764Pr-99
CEBPGdown-regulatesR-443-0.789852Pr-4
SP1up-regulatesR-2711-0.793825Pr-0
ELF4down-regulatesR-2350-0.794443Pr-22
HSF1down-regulatesR-51-0.803656Pr-19
FOXO1down-regulatesR-1394-0.807027Pr-0
BBXdown-regulatesR-1536-0.809151Pr-10
MAZup-regulatesR-508-0.810173Pr-0
STAT5Bup-regulatesR-23660.819111Pr-85
ELF1down-regulatesR-2995-0.821049Pr-117
ELF2down-regulatesR-9820.82189Pr-21
ZFXdown-regulatesR-1916-0.823941Pr-0
FOXK1down-regulatesR-1188-0.824193Pr-0
MAFKdown-regulatesR-28140.847631Pr-124
FOXK1down-regulatesR-1198-0.848863Pr-5
IRF9down-regulatesR-11490.851839Pr-124
RARAdown-regulatesR-159-0.860941Pr-9
IRF7down-regulatesR-1084-0.861526Pr-40
FOXJ3down-regulatesR-2874-0.864638Pr-6
FOXJ3down-regulatesR-2873-0.871109Pr-2
HSF1down-regulatesR-52-0.875962Pr-9
ZBTB3up-regulatesR-1264-0.885093Pr-9
HBP1down-regulatesR-18430.893682Pr-21
IRF1down-regulatesR-1820.909345Pr-124
POU2F1down-regulatesR-70-0.911223Pr-6
ARID3Aup-regulatesR-13400.91304Pr-124
FOXJ2down-regulatesR-1430-0.916894Pr-34
ETV3down-regulatesR-25310.919835Pr-136
ZEB1down-regulatesR-22380.929885Pr-136
FOXP1down-regulatesR-3119-0.932927Pr-0
STAT3down-regulatesR-301-0.935216Pr-0
ATF1up-regulatesR-559-0.936734Pr-0
BBXdown-regulatesR-15320.944278Pr-16
GABPB1down-regulatesR-1953-0.958675Pr-9
ZNF281down-regulatesR-2493-0.959313Pr-27
SREBF1up-regulatesR-11370.963749Pr-87
ERFdown-regulatesR-3310.969151Pr-136
IRF7down-regulatesR-1092-0.976053Pr-40
ATF4down-regulatesR-910.985038Pr-24
IRF1down-regulatesR-175-0.989721Pr-0
FOXO1down-regulatesR-1404-0.99049Pr-64
FOXJ3down-regulatesR-2870-0.999227Pr-0
POU2F1down-regulatesR-66-1.00411Pr-0
NR4A2down-regulatesR-1718-1.0054Pr-9
IRF9down-regulatesR-1152-1.01235Pr-40
CREB1down-regulatesR-2751.02424Pr-5
VDRdown-regulatesR-12281.0371Pr-87
RFX1down-regulatesR-2572-1.03711Pr-10
FOXO1down-regulatesR-1398-1.0377Pr-14
RREB1down-regulatesR-23011.03902Pr-59
SRFdown-regulatesR-1790-1.04379Pr-27
IRF7down-regulatesR-1090-1.0469Pr-40
NFKB1down-regulatesR-1585-1.04936Pr-4
CREB1down-regulatesR-273-1.05492Pr-9
NR3C1down-regulatesR-3185-1.06036Pr-0
IRF1down-regulatesR-192-1.06726Pr-40
TRAF4down-regulatesR-30341.06768Pr-124
SP1up-regulatesR-27131.08118Pr-87
CEBPGdown-regulatesR-433-1.08132Pr-0
ELK3down-regulatesR-28451.08229Pr-136
GABPB1down-regulatesR-19551.09101Pr-72
IRF9down-regulatesR-1154-1.10025Pr-40
RREB1down-regulatesR-2298-1.11227Pr-6
ELF4down-regulatesR-2329-1.11766Pr-6
ELF2down-regulatesR-964-1.11857Pr-58
SP1up-regulatesR-2728-1.12023Pr-9
FOXP1down-regulatesR-3141-1.12635Pr-3
FOXJ3down-regulatesR-28841.12637Pr-16
ATF1up-regulatesR-562-1.1286Pr-0
MAFKdown-regulatesR-2798-1.12983Pr-0
FOXJ2down-regulatesR-1418-1.1481Pr-0
IRF1down-regulatesR-195-1.1496Pr-9
FOXK1down-regulatesR-1189-1.15299Pr-2
ARID3Aup-regulatesR-1344-1.15545Pr-9
ARID3Aup-regulatesR-1353-1.16523Pr-10
POU2F1down-regulatesR-841.16934Pr-16
RFX3down-regulatesR-1673-1.17273Pr-10
RUNX3down-regulatesR-903-1.18553Pr-10
MAZup-regulatesR-503-1.19474Pr-9
RARAdown-regulatesR-1571.1957Pr-117
ATF1up-regulatesR-571-1.19606Pr-10
ELF4down-regulatesR-2341-1.20013Pr-25
STAT4down-regulatesR-2657-1.22095Pr-10
CEBPGdown-regulatesR-4441.22162Pr-23
ERFdown-regulatesR-333-1.22378Pr-3
RREB1down-regulatesR-22901.22484Pr-16
SRFdown-regulatesR-1789-1.22568Pr-1
RARAdown-regulatesR-1641.24046Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MEF2Adown-regulatesR-1878-1.24921Pr-9
ZNF281down-regulatesR-2488-1.25749Pr-0
IRF1down-regulatesR-1941.26041Pr-3
RORAdown-regulatesR-2279-1.26921Pr-27
ARID3Aup-regulatesR-1350-1.27345Pr-5
MAFKdown-regulatesR-2806-1.27994Pr-9
FOXP1down-regulatesR-31281.29587Pr-16
EWSR1down-regulatesR-2558-1.30814Pr-27
MEF2Adown-regulatesR-18711.35384Pr-16
RARAdown-regulatesR-1481.3622Pr-5
CEBPGdown-regulatesR-448-1.37561Pr-10
ARID3Aup-regulatesR-13451.3836Pr-137
MEF2Adown-regulatesR-1888-1.38486Pr-22
NFKB1down-regulatesR-1583-1.38564Pr-9
ELF4down-regulatesR-2340-1.40118Pr-9
E2F2up-regulatesR-29491.40408Pr-16
ZEB1down-regulatesR-2239-1.40877Pr-34
ZNF281down-regulatesR-2480-1.41308Pr-9
MLXup-regulatesR-31981.41369Pr-5
FOXO1down-regulatesR-1408-1.42694Pr-9
FLI1down-regulatesR-789-1.43137Pr-19
RFX1down-regulatesR-2570-1.43236Pr-9
EWSR1down-regulatesR-2553-1.45023Pr-0
FOXJ3down-regulatesR-2892-1.46097Pr-10
FOXK1down-regulatesR-1205-1.46171Pr-10
STAT4down-regulatesR-2654-1.46619Pr-9
RFX1down-regulatesR-2569-1.47032Pr-5
SMAD4down-regulatesR-23581.49431Pr-117
FOXP1down-regulatesR-31231.51064Pr-24
CREB1down-regulatesR-277-1.54447Pr-35
ZBTB3up-regulatesR-12711.5513Pr-117
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
MAFKdown-regulatesR-2802-1.60272Pr-25
RREB1down-regulatesR-22821.60852Pr-5
SPDEFdown-regulatesR-1976-1.62216Pr-10
ZFXdown-regulatesR-1918-1.62764Pr-10
ETV6down-regulatesR-6951.6427Pr-136
IRF1down-regulatesR-199-1.64611Pr-124
EWSR1down-regulatesR-2551-1.6617Pr-19
RFX1down-regulatesR-25661.66776Pr-136
NR3C1down-regulatesR-3194-1.67228Pr-27
MAFKdown-regulatesR-2815-1.67228Pr-27
ELF4down-regulatesR-2346-1.67456Pr-5
RORAdown-regulatesR-22651.67679Pr-5
ZNF281down-regulatesR-2491-1.68427Pr-10
RFX3down-regulatesR-16571.68517Pr-60
IRF9down-regulatesR-11551.69513Pr-3
FOXJ2down-regulatesR-14211.70246Pr-136
RARAdown-regulatesR-1561.71471Pr-16
ZBTB4down-regulatesR-20901.72041Pr-117
EWSR1down-regulatesR-25501.72058Pr-56
HBP1down-regulatesR-18271.73978Pr-136
SPDEFdown-regulatesR-1961-1.74175Pr-17
MAZup-regulatesR-511-1.75904Pr-0
MAZup-regulatesR-501-1.77175Pr-19
HSF1down-regulatesR-56-1.77472Pr-36
FOXO1down-regulatesR-14091.77972Pr-21
NFKB1down-regulatesR-1588-1.78822Pr-3
ETV3down-regulatesR-2539-1.80906Pr-42
ATF1up-regulatesR-560-1.81953Pr-4
MAZup-regulatesR-4951.8487Pr-87
GABPB1down-regulatesR-19461.88107Pr-109
NRF1down-regulatesR-27051.91369Pr-136
FOXK1down-regulatesR-1202-1.92921Pr-28
NRF1down-regulatesR-27041.94607Pr-117
RREB1down-regulatesR-2302-1.95334Pr-10
RFX3down-regulatesR-16691.97317Pr-21
CREB1down-regulatesR-274-1.97415Pr-10
FOXO1down-regulatesR-1412-1.97656Pr-28
IKZF1down-regulatesR-9941.98155Pr-117
RFX3down-regulatesR-16752.03925Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

RFX3down-regulatesR-1678-2.04824Pr-22
RORAdown-regulatesR-22662.05916Pr-136
EP300down-regulatesR-2432-2.06462Pr-4
ETV3down-regulatesR-2532-2.0819Pr-3
ZEB1down-regulatesR-2243-2.08616Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

IRF7down-regulatesR-1089-2.10194Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

BARX2down-regulatesR-2912.13395Pr-137
CREB1down-regulatesR-270-2.13915Pr-4
FOXP1down-regulatesR-3124-2.15985Pr-17
VBP1up-regulatesR-2099-2.16715Pr-4
TRAF4down-regulatesR-3035-2.1684Pr-17
TRAF4down-regulatesR-3044-2.17055Pr-86
E2F1up-regulatesR-2176-2.17422Pr-61
FOXK1down-regulatesR-1194-2.1796Pr-17
ELK3down-regulatesR-28472.18224Pr-135
FLI1down-regulatesR-7842.19671Pr-137
SP1up-regulatesR-2733-2.20943Pr-20
IKZF1down-regulatesR-9962.22566Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

ARID3Aup-regulatesR-13382.23222Pr-60
SRFdown-regulatesR-1778-2.26549Pr-4
SPDEFdown-regulatesR-1967-2.26981Pr-19
CREB1down-regulatesR-278-2.27835Pr-11
TCF7L1down-regulatesR-3170-2.27892Pr-14
GABPB1down-regulatesR-1957-2.2937Pr-118
RELAdown-regulatesR-1463-2.30399Pr-4
RREB1down-regulatesR-2286-2.31249Pr-17
ETV6down-regulatesR-7142.32455Pr-72
MAZup-regulatesR-499-2.32628Pr-11
IRF1down-regulatesR-176-2.33755Pr-4
ELF2down-regulatesR-987-2.34496Pr-20
NFKB1down-regulatesR-1573-2.35352Pr-4
NR4A2down-regulatesR-1716-2.35911Pr-17
MAFKdown-regulatesR-2804-2.38089Pr-11
FOXO1down-regulatesR-1399-2.38797Pr-17
MEF2Adown-regulatesR-18812.39457Pr-21
HBP1down-regulatesR-1845-2.40009Pr-6
BBXdown-regulatesR-15332.412Pr-137
MAFKdown-regulatesR-2799-2.41258Pr-4
RARAdown-regulatesR-1692.42125Pr-138
POU2F1down-regulatesR-68-2.42589Pr-4
FOXJ3down-regulatesR-2877-2.43517Pr-86
ERFdown-regulatesR-3352.46806Pr-136
FOXJ2down-regulatesR-1422-2.47001Pr-86
IRF7down-regulatesR-1094-2.51148Pr-35
ETV6down-regulatesR-6932.52969Pr-72
CEBPGdown-regulatesR-4452.53867Pr-21
IKZF1down-regulatesR-990-2.55623Pr-4
RREB1down-regulatesR-2297-2.5711Pr-20
HBP1down-regulatesR-18372.57298Pr-21
STAT4down-regulatesR-2658-2.58346Pr-4
FOXP1down-regulatesR-3132-2.58418Pr-11
GABPB1down-regulatesR-19442.5919Pr-55
ZBTB7Bup-regulatesR-12332.59774Pr-52
MEF2Adown-regulatesR-1867-2.61348Pr-86
FOXO1down-regulatesR-1416-2.62977Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RFX3down-regulatesR-1674-2.69724Pr-19
ZNF281down-regulatesR-2487-2.70466Pr-4
FLI1down-regulatesR-7952.77664Pr-50
HBP1down-regulatesR-1829-2.78136Pr-17
NFIL3down-regulatesR-1684-2.82079Pr-4
ELF4down-regulatesR-2348-2.83012Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ENSG00000105991down-regulatesR-229-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

ZNF282up-regulatesR-20142.85693Pr-14
NRF1down-regulatesR-27032.85746Pr-72
ETV6down-regulatesR-6962.86125Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ATF4down-regulatesR-95-2.89504Pr-10
CEBPGdown-regulatesR-446-2.9189Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXJ2down-regulatesR-1439-2.93208Pr-11
ELF4down-regulatesR-2330-2.93229Pr-17
FOXK1down-regulatesR-1201-2.93735Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ETV3down-regulatesR-25302.93772Pr-72
ELF1down-regulatesR-29892.94799Pr-133
MAZup-regulatesR-513-2.96542Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

HINFPdown-regulatesR-2621-2.97505Pr-35
ELF1down-regulatesR-29862.98171Pr-74
SPDEFdown-regulatesR-1966-2.98845Pr-11
E2F2up-regulatesR-2948-3.01545Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FOXO1down-regulatesR-1405-3.01812Pr-11
TRAF4down-regulatesR-30413.08861Pr-50
MYBL2up-regulatesR-6563.10274Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

RORAdown-regulatesR-22713.11738Pr-138
MAFKdown-regulatesR-2813-3.12874Pr-4
RARAdown-regulatesR-153-3.1944Pr-61
MEF2Adown-regulatesR-1877-3.20022Pr-38
NFKB1down-regulatesR-1589-3.21935Pr-3
MAZup-regulatesR-5053.21974Pr-70
RORAdown-regulatesR-22763.22686Pr-50
NR3C1down-regulatesR-3189-3.2767Pr-20
FOXK1down-regulatesR-12103.29949Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

RELAdown-regulatesR-14643.32257Pr-70
SP1up-regulatesR-27153.33045Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

FOXO1down-regulatesR-1413-3.33652Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

NR3C1down-regulatesR-31883.34354Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

TRIM28down-regulatesR-1506-3.3709Pr-35
MYBup-regulatesR-620-3.37541Pr-38
ZEB1down-regulatesR-2241-3.39487Pr-11
RELAdown-regulatesR-1465-3.41018Pr-17
IRF9down-regulatesR-1156-3.43888Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

SMAD4down-regulatesR-2355-3.44256Pr-86
EWSR1down-regulatesR-2555-3.47017Pr-0
ZFXdown-regulatesR-19293.48789Pr-117
ZEB1down-regulatesR-2253-3.48803Pr-86
ETV6down-regulatesR-7123.48831Pr-74
SPDEFdown-regulatesR-19733.49659Pr-50
MAZup-regulatesR-512-3.50135Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

ZFXdown-regulatesR-1921-3.52781Pr-11
ZBTB3up-regulatesR-1269-3.55836Pr-135
VDRdown-regulatesR-1229-3.57357Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

RARAdown-regulatesR-166-3.60154Pr-20
RFX3down-regulatesR-16683.60705Pr-138
STAT3down-regulatesR-307-3.61941Pr-11
NFKB1down-regulatesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

GABPB1down-regulatesR-1945-3.71816Pr-35
EWSR1down-regulatesR-25543.72615Pr-50
ELF1down-regulatesR-29783.77589Pr-52
BACH1down-regulatesR-470-3.77843Pr-17
FOXK1down-regulatesR-1196-3.80774Pr-11
SP1up-regulatesR-2726-3.82052Pr-20
HBP1down-regulatesR-18423.856Pr-138
SP1up-regulatesR-27163.88928Pr-52
ZNF281down-regulatesR-2484-3.91355Pr-20
GABPB1down-regulatesR-19513.93668Pr-50
SP1up-regulatesR-2734-3.98682Pr-38
ELF1down-regulatesR-29834.09607Pr-50
SRFdown-regulatesR-17814.13916Pr-70
E2F8up-regulatesR-16294.14363Pr-136
RREB1down-regulatesR-2287-4.14495Pr-100
CEBPGdown-regulatesR-4414.14664Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-4964.15346Pr-52
SPDEFdown-regulatesR-1963-4.23229Pr-35
POU2F1down-regulatesR-884.3225Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ATF1up-regulatesR-566-4.35783Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ELF1down-regulatesR-29764.38806Pr-70
ELF1down-regulatesR-2980-4.39203Pr-61
MEF2Adown-regulatesR-18804.46094Pr-128
ZEB1down-regulatesR-2244-4.47087Pr-35
NRF1down-regulatesR-27104.52843Pr-72
RFX3down-regulatesR-16654.55866Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-734.62299Pr-70
ELF1down-regulatesR-29754.75926Pr-48
MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-864.85124Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-506-4.85353Pr-4
HBP1down-regulatesR-18474.92709Pr-70
RORAdown-regulatesR-22814.95755Pr-70
ELF2down-regulatesR-9754.96438Pr-74
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ELF1down-regulatesR-29925.06585Pr-70
MAZup-regulatesR-5045.11311Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

ERFdown-regulatesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RORAdown-regulatesR-2277-5.15649Pr-36
SPDEFdown-regulatesR-19655.28567Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ETV6down-regulatesR-7035.54512Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FOXO1down-regulatesR-1407-6.04696Pr-130
VDRdown-regulatesR-1230-6.13961Pr-135
FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SP1up-regulatesR-27196.73271Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

PARP1up-regulatesR-26368.12838Pr-68
FOXO1down-regulatesR-13938.37511Pr-68
MYBup-regulatesR-6148.54513Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions